104315-07-3

Basic information

• Product Name: ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE
• Synonyms: ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE;(2E)-3-[4-(PhenylMethoxy)phenyl]-2-propenoic Acid Ethyl Ester;Ethyl (E)-3-[4-(benzyloxy)phenyl]-2-propenoate;3-(4-Benzyloxy-phenyl)-acrylic acid ethyl ester
• CAS NO: 104315-07-3
• Molecular Formula: C₁₈H₁₈O₃
• Molecular Weight: 282.33
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 104315-07-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 96-97°
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE(104315-07-3)
• EPA Substance Registry System: ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE(104315-07-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 104315-07-3(Hazardous Substances Data)

Usage

Description

ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE, also known as (2E)-3-[4-(Phenylmethoxy)phenyl]-2-propenoic Acid Ethyl Ester, is a chemical compound with the CAS number 104315-07-3. It is primarily used in organic synthesis due to its unique structure and properties.

Uses

Used in Organic Synthesis:
ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE is used as a key intermediate in the synthesis of various organic compounds. Its benzyloxyphenyl group and ethyl ester functionality make it a versatile building block for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE is used as a starting material for the synthesis of drug candidates. Its reactivity and structural features allow for the creation of novel molecules with potential therapeutic applications.
Used in Agrochemical Industry:
ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE also finds application in the agrochemical industry, where it serves as a precursor for the development of new pesticides and other crop protection agents. Its unique structure can be utilized to design molecules with improved efficacy and selectivity.
Used in Specialty Chemicals:
In the specialty chemicals sector, ETHYL 3-[4-(BENZYLOXY)PHENYL]ACRYLATE is employed as a raw material for the production of various high-value chemicals. Its functional groups and aromatic system enable the synthesis of compounds with specific properties, such as UV absorbers, dyes, and other performance-enhancing additives.

Upstream product

• 154140-38-2 (S)-3-(4-Benzyloxy-phenyl)-3-hydroxy-propionic acid ethyl ester 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 2979-06-8 ethyl (E)-4-hydroxycinnamate 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 53090-45-2 ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate 
• 328396-03-8 (-)-ethyl 3-(4-benzyloxyphenyl)-3-hydroxypropionate 
• 1071-46-1 hydrogen ethyl malonate 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 22171-15-9 4-(benzyloxy)benzylamine 

Downstream Products

• 444154-77-2 (2S,3R)-2-benzyloxycarbonylamino-3-(4-benzyloxyphenyl)-3-hydroxypropioic acid 
• 84184-52-1 (E)-3-(4-(benzyloxy)phenyl)prop-2-en-1-ol 
• 853785-01-0 (E)-1-(4-benzyloxyphenyl)hex-1-en-3-ol 
• 853785-08-7 acetic acid (R)-1-[(E)-2-(4-benzyloxyphenyl)vinyl]butyl ester 
• 84184-53-2 4-benzyloxycinnamaldehyde 

Relevant articles and documents

Accessing dihydro-1,2-oxazine via cloke-wilson-type annulation of cyclopropyl carbonyls: application toward the diastereoselective synthesis of pyrrolo[1,2- b][1,2]oxazine

A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson-type ring expansion of the aryl-substituted cyclopropane carbaldehydes with the hydroxylamine salt is introduced. Comparatively less active cyclopropyl ketones also follow a similar protocol if supplemented by catalytic p-toluene sulfonic acid monohydrate. The transformation is performed in an open-to-air flask as it shows negligible sensitivity toward air/moisture. Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester afford a trouble-free formulation of the valued hexahydro-2H-pyrrolo[1,2-b][1,2]oxazine derivatives. A cascade one-pot variant of this two-step strategy offers a comparable overall yield of the final product.

Electrochemical Generation of a Nonstabilized Azomethine Ylide: Access to Substituted N-Heterocycles

Azomethine ylides are fascinating 1,3-dipoles for [3 + 2] cycloaddition reactions toward the construction ofN-heterocycles. Herein, an efficient and environmentally benign electrochemical approach for the generation of a nonstabilized azomethine ylide has been established under metal-free and external oxidant-free conditions. The resulting 1,3-dipole undergoes a [3 + 2] cycloaddition reaction with olefins. This electrosynthetic methodology indulges a straightforward and facile approach for the construction of substituted pyrrolidines.

Metal-free domino Cloke-Wilson rearrangement-hydration-dimerization of cyclopropane carbaldehydes: A facile access to oxybis(2-aryltetrahydrofuran) derivatives

In this work, we have demonstrated a metal-free transformation of cyclopropane carbaldehydes to oxybis(2-aryltetrahydrofuran) derivatives via a domino Cloke-Wilson rearrangement-hydration-dimerization sequence. Commercially inexpensive p-toluene sulfonic acid (PTSA) was used as a Br?nsted acid catalyst, and reactions were conducted in an open-flask. Detection of reaction intermediates were carried to get an insight into the reaction pathway.