1043468-87-6

Basic information

• Product Name: 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
• Synonyms: 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
• CAS NO: 1043468-87-6
• Molecular Weight: 621.125
• Mol File: 1043468-87-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate(1043468-87-6)
• EPA Substance Registry System: 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate(1043468-87-6)

Safety Data

• Hazardous Substances Data: 1043468-87-6(Hazardous Substances Data)

Upstream product

• 847682-00-2 1,3-bis(2,2-dimethyl-1,3-dioxan-5-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate 
• 65178-90-7 2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropionyl chloride 
• 42017-89-0 fenofibric acid 

Downstream Products

• 1043468-82-1 1,3-bis(1,3-dihydroxypropan-2-yloxy)propan-2-yl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate 

Relevant articles and documents

Synthesis of highly water-soluble fibrate derivatives via BGLation

Three water-soluble fibrates (fenofibrate, bezafibrate and chlofibrate) conjugated with a symmetrically branched glyceryl trimer (BGL003) were synthesized, and an evaluation of the fenofibrate-BGL003 conjugate as a candidate for anti-hyperlipemia drug was carried out using rats. The water-solubility of the fenofibrate-BGL003 conjugate was several thousand times greater than that of the original fenofibrate. The lipid-lowering effects of the fenofibrate-BGL003 conjugate were as strong as those of the same grams of fenofibrate. The actual active species of fenofibrate, fenofibric acid, was detected in rats' blood, but neither the fenofibrate-BGL003 conjugate nor fenofibrate was detected, probably due to enzymatic hydrolysis of the ester bond. The plasma concentration of fenofibric acid derived from the fenofibrate-BGL003 conjugate was five times higher than that derived from fenofibrate 4 h after administration.