104393-81-9

Basic information

• Product Name: 1-HEXYL-4-PHENYL-PIPERAZINE
• Synonyms: Piperazine, 1-hexyl-4-phenyl-
• CAS NO: 104393-81-9
• Molecular Formula: C₁₆H₂₆N₂
• Molecular Weight: 246.39
• Mol File: 104393-81-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-HEXYL-4-PHENYL-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HEXYL-4-PHENYL-PIPERAZINE(104393-81-9)
• EPA Substance Registry System: 1-HEXYL-4-PHENYL-PIPERAZINE(104393-81-9)

Safety Data

• Hazardous Substances Data: 104393-81-9(Hazardous Substances Data)

Usage

General Description

1-HEXYL-4-PHENYL-PIPERAZINE is a chemical compound with the molecular formula C18H28N2. It is a piperazine derivative with a hexyl chain attached to the nitrogen atom and a phenyl group attached to the piperazine ring. 1-HEXYL-4-PHENYL-PIPERAZINE has been studied for its potential use in the treatment of various medical conditions, including neurological disorders. It has also been researched for its potential as a psychoactive substance and has been used in scientific studies related to behavioral and pharmacological effects. Additionally, 1-HEXYL-4-PHENYL-PIPERAZINE is listed as a controlled substance in certain countries due to its potential for abuse and dependence.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 111-25-1 1-bromo-hexane 
• 638-45-9 1-Iodohexane 
• 66-25-1 hexanal 
• 62-53-3 aniline 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 111-27-3 hexan-1-ol 

Downstream Products

• 104393-85-3 C₁₆H₂₅⁽¹²⁵⁾IN₂ 
• 339074-49-6 N'-(4-formylphenyl)-N-hexylpiperazine 
• 112899-01-1 N-hexyl-N'-<4-(1-hydroxyhexyl)phenyl>piperazine 
• 112898-84-7 N'-(4-hexanoylphenyl)-N-hexylpiperazine 
• 112898-95-0 N-[1-[4-(4-Hexyl-piperazin-1-yl)-phenyl]-meth-(E)-ylidene]-N'-phenyl-hydrazine 

Relevant articles and documents

Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C-N bond formation

An efficient copper-catalyzed tandem synthesis of N-alkyl-N′-aryl-piperazines from 1,4-diaza-bicyclo[2.2.2]octane, alkyl halides, and aryl halides in the presence of copper(I) iodide and potassium tert-butoxide in DMSO is described.

Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures

Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the reaction includes aliphatic acyclic and cyclic ketones, aliphatic and aromatic aldehydes, and primary and secondary amines including a variety of weakly basic and nonbasic amines. Limitations include reactions with aromatic and unsaturated ketones and some sterically hindered ketones and amines. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran (THF) and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions, but it is generally not needed with aldehydes. The procedure is carried out effectively in the presence of acid sensitive functional groups such as acetals and ketals; it can also be carried out in the presence of reducible functional groups such as C-C multiple bonds and cyano and nitro groups. Reactions are generally faster in DCE than in THF, and in both solvents, reactions are faster in the presence of AcOH. In comparison with other reductive amination procedures such as NaBH3CN/MeOH, borane-pyridine, and catalytic hydrogenation, NaBH(OAc)3 gave consistently higher yields and fewer side products. In the reductive amination of some aldehydes with primary amines where dialkylation is a problem we adopted a stepwise procedure involving imine formation in MeOH followed by reduction with NaBH4.

Structure-activity relationship studies of CNS agents. Part 16: A lower limit of a distance between crucial pharmacophores of 5-HT(1A) ligands

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