1044148-89-1

Basic information

• Product Name: 4-[di(tert-butoxycarbonyl)aMino]-2-broMopyridine
• Synonyms: 4-[di(tert-butoxycarbonyl)aMino]-2-broMopyridine;2-Bromo-4-(di-Boc-amino)pyridine, 95%
• CAS NO: 1044148-89-1
• Molecular Formula: C15H21BrN2O4
• Molecular Weight: 373.24224
• EINECS: -0
• Mol File: 1044148-89-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[di(tert-butoxycarbonyl)aMino]-2-broMopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[di(tert-butoxycarbonyl)aMino]-2-broMopyridine(1044148-89-1)
• EPA Substance Registry System: 4-[di(tert-butoxycarbonyl)aMino]-2-broMopyridine(1044148-89-1)

Safety Data

• Hazardous Substances Data: 1044148-89-1(Hazardous Substances Data)

Upstream product

• 7598-35-8 2-bromo-4-aminopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology

It is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of Alzheimer's disease (AD). For selective detection of tau pathology, we synthesized and evaluated radioiodinated benzoimidazopyridine (BIP) derivatives with an alkylamino group as tau imaging probes. In vitro selectivity to tau aggregates and in vivo pharmacokinetics of BIP derivatives varied markedly, being strongly dependent on the alkylamino group. In in vitro autoradiography with AD brain sections, the BIP derivative with a dimethylamino group (BIP-NMe2) showed the highest selectivity to tau aggregates. Regarding the biodistribution using normal mice, the BIP derivative with an ethylamino group (BIP-NHEt) showed the highest uptake (6.04% ID/g at 2 min postinjection) into and rapid washout (0.12% ID/g at 60 min postinjection) from the brain. These results suggest that the introduction of an optimal alkylamino group into the BIP scaffold may lead to the development of more potential tau imaging probes.