104435-86-1

Basic information

• Product Name: Benzoic acid, 4-[[6-[(cyclopentylacetyl)amino]-1H-indol-1-yl]methyl]-3-methoxy-, methyl ester
• CAS NO: 104435-86-1
• Molecular Formula: C25H28N2O4
• Molecular Weight: 420.508
• Mol File: 104435-86-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[6-[(cyclopentylacetyl)amino]-1H-indol-1-yl]methyl]-3-methoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[6-[(cyclopentylacetyl)amino]-1H-indol-1-yl]methyl]-3-methoxy-, methyl ester(104435-86-1)
• EPA Substance Registry System: Benzoic acid, 4-[[6-[(cyclopentylacetyl)amino]-1H-indol-1-yl]methyl]-3-methoxy-, methyl ester(104435-86-1)

Safety Data

• Hazardous Substances Data: 104435-86-1(Hazardous Substances Data)

Upstream product

• 1123-00-8 2-cyclopentylacetic acid 
• 104446-67-5 methyl 4-<(6-aminoindol-1-yl)methyl>-3-methoxybenzoate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 70264-94-7 methyl 4-(bromomethyl)-3-methoxybenzoate 
• 7151-68-0 3-methoxy-p-toluic acid 
• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 104437-17-4 methyl 3-methoxy-4-<(6-nitroindol-1-yl)methyl>benzoate 

Downstream Products

• 104436-23-9 4-[6-(2-Cyclopentyl-acetylamino)-indol-1-ylmethyl]-3-methoxy-benzoic acid 

Relevant articles and documents

Evolution of a Series of Peptidoleukotriene Antagonists: Synthesis and Structure-Activity Relationships of 1,6-Disubstituted Indoles and Indazoles

A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the leukotrienes themselves) led to the discovery of a novel class of indole and indazole derived antagonists of peptidoleukotrienes.A systematic exploration of C-6 substituted 4-(indol-1-ylmethyl)-3-methoxybenzoic acids identified cyclopentylacetamide and cyclopentylurethane as preferred substituents.The corresponding indazoles were equipotent.These compounds are selective leukotriene antagonists with pKB values of 7.5-7.8 vs LTE4 on guinea pig trachea.