1044499-65-1

Basic information

• Product Name: (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one
• Synonyms: (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one
• CAS NO: 1044499-65-1
• Molecular Weight: 359.384
• Mol File: 1044499-65-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one(1044499-65-1)
• EPA Substance Registry System: (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one(1044499-65-1)

Safety Data

• Hazardous Substances Data: 1044499-65-1(Hazardous Substances Data)

Upstream product

• 1044499-63-9 C₂₂H₁₆F₃N₃O₆S 
• 28144-70-9 anthranilic acid amide 
• 108934-21-0 4-(2'-methylphenyl)benzaldehyde 

Relevant articles and documents

Chiral Phosphoric Acids in Metal–Organic Frameworks with Enhanced Acidity and Tunable Catalytic Selectivity

Chiral phosphoric acids are incorporated into indium-based metal–organic frameworks (In-MOFs) by sterically preventing them from coordination. This concept leads to the synthesis of three chiral porous 3D In-MOFs with different network topologies constructed from three enantiopure 1,1′-biphenol-phosphoric acid derived tetracarboxylate linkers. More importantly, all the uncoordinated phosphoric acid groups are periodically aligned within the channels and display significantly enhanced acidity compared to the non-immobilized acids. This facilitates the Br?nsted acid catalysis of asymmetric condensation/amine addition and imine reduction. The enantioselectivities can be tuned (up to '99 % ee) by varying the substituents to achieve a nearly linear correlation with the concentrations of steric bulky groups in the MOFs. DFT calculations suggest that the framework provides a chiral confined microenvironment that dictates both selectivity and reactivity of chiral MOFs.