104478-93-5

Basic information

• Product Name: N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE
• Synonyms: N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE;AKOS BBV-007764;propanamide, N-(4-aminophenyl)-2,2-dimethyl-;N-(4-aminophenyl)-2,2-dimethylpropanamide(SALTDATA: FREE);N-(4-aminophenyl)-2,2-dimethyl-propionamide
• CAS NO: 104478-93-5
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 104478-93-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 300.2°C at 760 mmHg
• Flash Point: 135.4°C
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 0.00114mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE(104478-93-5)
• EPA Substance Registry System: N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE(104478-93-5)

Safety Data

• Hazardous Substances Data: 104478-93-5(Hazardous Substances Data)

Usage

General Description

"N-(4-aminophenyl)-2,2-dimethylpropanamide" is a chemical compound with the molecular formula C11H16N2O. It is classified as an amide, which is a functional group containing a carbonyl group attached to a nitrogen atom. N-(4-AMINOPHENYL)-2,2-DIMETHYLPROPANAMIDE is also known as a local anesthetic called benzocaine, which is commonly used to relieve pain and itching caused by conditions such as sunburn or insect bites. It works by blocking nerve signals in the body, thereby reducing the sensation of pain. Benzocaine is considered safe for use when applied to the skin or mucous membranes in appropriate concentrations. However, it is important to use caution and follow the recommended dosage instructions to avoid potential side effects or allergic reactions.

InChI:InChI=1/C11H16N2O/c1-11(2,3)10(14)13-9-6-4-8(12)5-7-9/h4-7H,12H2,1-3H3,(H,13,14)

Upstream product

• 56619-95-5 2,2-dimethyl-N-(4-nitrophenyl)propionamide 
• 3282-30-2 pivaloyl chloride 
• 100-01-6 4-nitro-aniline 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 

Downstream Products

• 87223-44-7 C₁₆H₂₂N₄O₅ 
• 233254-30-3 4-acetamidonaphthalene-1-sulphonic acid N-[4-(N-2,2-dimethylpropanoyl)aminophenyl]amide 

Relevant articles and documents

Esterification of Tertiary Amides: Remarkable Additive Effects of Potassium Alkoxides for Generating Hetero Manganese–Potassium Dinuclear Active Species

A catalyst system of mononuclear manganese precursor 3 combined with potassium alkoxide served as a superior catalyst compared with our previously reported manganese homodinuclear catalyst 2 a for esterification of not only tertiary aryl amides, but also tertiary aliphatic amides. On the basis of stoichiometric reactions of 3 and potassium alkoxide salt, kinetic studies, and density functional theory (DFT) calculations, we clarified a plausible reaction mechanism in which in situ generated manganese–potassium heterodinuclear species cooperatively activates the carbonyl moiety of the amide and the OH moiety of the alcohols. We also revealed details of the reaction mechanism of our previous manganese homodinuclear system 2 a, and we found that the activation free energy (ΔG≠) for the manganese–potassium heterodinuclear complex catalyzed esterification of amides is lower than that for the manganese homodinuclear system, which was consistent with the experimental results. We further applied our catalyst system to deprotect the acetyl moiety of primary and secondary amines.

Boron trifluoride-methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity

A boron trifluoride-methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.

A new class of low-molecular-weight amphiphilic gelators

A new powerful class of low-molecular-weight amphiphilic compounds has been synthesized and their structure-property relationships with respect to their gelation ability of organic solvents have been investigated. These compounds are able to gel organic solvents over a broad range of polarity. Especially polar solvents such as valeronitrile and γ-butyrolactone can be gelled even at concentrations far below 1 wt %. It was found that the gelation ability of these asymmetrically substituted p-phenylendiamines depends on a well-balanced relation of the terminal head group, the units involved in hydrogen bonding (amide or urea groups), and on the length of the alkyl chain. With this class of new gelators it is possible to tailor thermal and mechanical properties in different organic solvents and open various application possibilities.