104483-01-4

Basic information

• Product Name: 1-(4-isobutyl-phenyl)-1-butanone
• Synonyms: 1-(4-isobutyl-phenyl)-1-butanone
• CAS NO: 104483-01-4
• Molecular Weight: 204.312
• Mol File: 104483-01-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(4-isobutyl-phenyl)-1-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-isobutyl-phenyl)-1-butanone(104483-01-4)
• EPA Substance Registry System: 1-(4-isobutyl-phenyl)-1-butanone(104483-01-4)

Safety Data

• Hazardous Substances Data: 104483-01-4(Hazardous Substances Data)

Upstream product

• 611-70-1 phenyl isopropyl ketone 
• 538-93-2 1-phenyl-2-methylpropane 
• 141-75-3 butyryl chloride 

Downstream Products

• 112026-22-9 (6-(benzyloxy)hexyl)magnesium bromide 
• 146939-63-1 ethyl (S)-4-[1-[4-[[1-(4-isobutylphenyl)butyl]oxy]benzoyl]indolizin-3-yl]butyrate 
• 146939-65-3 ethyl (R)-4-[1-[4-[[1-(4-isobutylphenyl)butyl]oxy]benzoyl]indolizin-3-yl]butyrate 
• 148366-86-3 4-(3-{4-[(S)-1-(4-Isobutyl-phenyl)-butoxy]-benzoyl}-indol-1-yl)-butyric acid ethyl ester 
• 148366-85-2 4-(3-{4-[(R)-1-(4-Isobutyl-phenyl)-butoxy]-benzoyl}-indol-1-yl)-butyric acid ethyl ester 
• 146939-46-0 ethyl 4-[1-[4-[1-(4-isobutylphenyl)butyloxy]benzoyl]indolizin-3-yl]butyrate 
• 148366-61-4 ethyl 4-[3-[4-[1-(4-isobutylphenyl)butoxy]benzoyl]indol-1-yl]butyrate 
• 148367-07-1 1-(1-Bromobutyl)-4-isobutylbenzene 
• 146922-85-2 (S)-1-(4-Isobutyl-phenyl)-butan-1-ol 
• 146922-84-1 (R)-1-(4-isobutylphenyl)butan-1-ol 
• 148367-03-7 1-(4-Isobutylphenyl)butan-1-ol 
• 62449-91-6 1-n-butyl-4-i-butylbenzene 

Relevant articles and documents

4-(Benzoylindolizinyl)butyric acids; novel nonsteroidal inhibitors of steroid 5α-reductase. III

A novel series of indolizinebutyric acids with various benzoyl substituents was synthesized to develop nonsteroidal inhibitors of steroid 5α-reductase, and the structure-activity relationships in this series were studied. We previously reported the structure-activity relationships in a series of indolebutyric acids as well as the discovery of the novel nonsteroidal 5α-reductase inhibitor, FK143. We have now made other modifications to this compound to improve in vivo inhibitory activity. By altering the heterocyclic nucleus and changing the benzoyl substituent we have succeeded in identifying the strongly active compound, FK687, (S)-4-[1-[4-[[1-(4-isobutylphenyl)butyl]oxy]benzoyl]indolizin-3-yllbutyric acid, which displays strong in vitro inhibitory activity against the human enzyme and in vivo inhibitory activity against the castrated young rat model. This compound should be a useful agent for the treatment of benign prostatic hyperplasia.

Process for preparing α-hydroxy-acids and compounds obtained by this process

The invention relates to a process for preparing α-hydroxy-acids of general formula: STR1 in which R represents hydrogen or a lower alkyl radical and Cy represents a phenyl, naphthyl or heterocyclic radical, these latter three radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy radicals and halogen atoms, process which comprises the treatment of an α-monohalogenated ketone of general formula: STR2 in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide, a non-polar organic solvent selected from an aromatic or alicyclic hydrocarbon and oxygen in excess optionally in the presence of an inert gas, the treatment being carried out at a temperature ranging from the boiling temperature of the reaction medium at atmospheric pressure and 240° C. under pressure and the alkali metal so formed is then acidified to obtain the desired acid.