104498-96-6Relevant articles and documents
Structural Studies on Bio-active Compounds. Part 3. Re-examination of the Hydrolysis of the Antimalarial Drug Pyrimethamine and Related Derivatives and Crystal Structure of a Hydrolysis Product
Griffin, Roger J.,Schwalbe, Carl H.,Stevens, Malcolm F. G.,Wong, Kait P.
, p. 2267 - 2276 (2007/10/02)
Hydrolysis of the diaminopyrimidine pyrimethamine and some of its 5-(3'-substituted)phenyl derivatives with 6M-hydrochloric acid or deamination with nitrous acid, affords mixtures of isomeric aminopyrimidinones.The ratio of products is influenced by the n