1045-51-8

Basic information

• Product Name: 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide
• Synonyms: 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide;4-[(4-Chlorophenyl)amino]-1-phenylmethyl-4-piperidinecarboxamide
• CAS NO: 1045-51-8
• Molecular Formula: C₁₉H₂₂ClN₃O
• Molecular Weight: 343.85048
• EINECS: 213-875-0
• Mol File: 1045-51-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 559.5°Cat760mmHg
• Flash Point: 292.2°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 1.5E-12mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide(1045-51-8)
• EPA Substance Registry System: 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide(1045-51-8)

Safety Data

• Hazardous Substances Data: 1045-51-8(Hazardous Substances Data)

Usage

General Description

1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide is a synthetic chemical compound with potential pharmaceutical applications. It belongs to the class of piperidine derivatives and is structurally related to analgesic and anesthetic compounds. The presence of the benzyl, chlorophenyl, and piperidine moieties in its structure suggests that it may have potential activity on the central nervous system. 1-benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide could be a valuable tool for medicinal chemistry research and drug development, particularly in the design and synthesis of new analgesics and anesthetics with improved properties. Its detailed chemical and pharmacological properties are subjects of ongoing research.

InChI:InChI=1/C19H22ClN3O/c20-16-6-8-17(9-7-16)22-19(18(21)24)10-12-23(13-11-19)14-15-4-2-1-3-5-15/h1-9,22H,10-14H2,(H2,21,24)

Upstream product

• 972-20-3 1-benzyl-4-(4-chloro-phenylamino)-piperidine-4-carbonitrile 
• 106-47-8 4-chloro-aniline 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 227029-23-4 8-benzyl-1-(4-chlorophenyl)-1,3,8-triazaspiro[4.5]dec-2-en-4-one 
• 849106-07-6 1-benzyl-4-(4-chloro-phenylamino)-piperidine-4-carboxylic acid methyl ester 
• 849106-09-8 4-(4-chloro-phenylamino)-piperidine-4-carboxylic acid amide 
• 976-96-5 8-benzyl-1-(4-chlorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one 

Relevant articles and documents

1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY

The present invention relates to a 1,3,8-triazaspiro compound of Formula (I), wherein A is -CH2, -SO2 -, -NH-CO-, -NH-CS- or -CO-; the dashed line represents a single or double bond; R1 is a substituent selected from (C1-C3) alkyl, phenyl, thienyl and cyclohexyl, said substituent being optionally substituted by halogen or (C1 -C3) alkyl; and R2 is a substituent selected from H, (C1-C3) alkyl, (C1-C3) alkoxy, -CF3 and halogen; and wherein, when the dashed line is a double bond, A is -CH2 - and R1 is phenyl, or a pharmaceutically acceptable salt thereof for use in the treatment of reperfusion injury diseases. The 1,3,8-triazaspiro compound of the invention is a selective inhibitor of the C subunit of the F1/Fo-ATP synthase complex and a modulator of the mitochondrial permeability transition pore activity in mammalian cells and tissues, in the treatment of reperfusion injury diseases.

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

Chemokine receptor antagonists and methods of use thereof

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.