10450-11-0

Basic information

• Product Name: N-Cyclohexyl-2-benzoxazolamine
• Synonyms: 2-(Cyclohexylamino)benzoxazole;N-Cyclohexyl-2-benzoxazolamine
• CAS NO: 10450-11-0
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.28
• Mol File: 10450-11-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Cyclohexyl-2-benzoxazolamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclohexyl-2-benzoxazolamine(10450-11-0)
• EPA Substance Registry System: N-Cyclohexyl-2-benzoxazolamine(10450-11-0)

Safety Data

• Hazardous Substances Data: 10450-11-0(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 4694-88-6 benzooxazole-2-sulfonic acid; potassium salt 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 2382-96-9 benzo[d]oxazole-2-(3H)-thione 
• 538-75-0 dicyclohexyl-carbodiimide 
• 3743-70-2 N-(2-hydroxyphenyl)benzamide 
• 15175-40-3 1-Cyclohexyl-3-(2-hydroxy-phenyl)-thiourea 
• 1850-14-2 tetramethoxymethane 
• 95-55-6 2-amino-phenol 
• 273-53-0 benzoxazole 
• 766-93-8 N-cyclohexylformamide 
• 102675-92-3 2-iodo-1,3-benzoxazole 
• 18879-86-2 cyclohexylaminodithiocarboxylic acid, cyclohexylammonium salt 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 

Relevant articles and documents

Organocatalytic Visible Light Enabled SNAr of Heterocyclic Thiols: A Metal-Free Approach to 2-Aminobenzoxazoles and 4-Aminoquinazolines

The direct amination reaction of heterocyclic thiols has been developed in the presence of the nonhazardous photocatalyst Rose Bengal under irradiation of visible light. The reaction provides a straightforward approach to pharmaceutically and synthetically useful 2-aminobenzoxazole and 4-aminoquinazoline derivatives from the corresponding heterocyclic thiols with amines in good to excellent yields. Our photochemical reaction can be successfully adapted into a continuous flow reactor which is applicable for large-scale chemical industry. The key benefits of this reaction include the use of metal-free, low-cost Rose Bengal catalyst and practical operation (ambient temperature, open flask, and undried solvents).

A convenient one-pot synthesis of N-substituted 2-aminoazole derivatives

A practical protocol for the one-pot synthesis of N-substituted 2-aminoazole derivatives is described, employing simple azole substrates, nitrogen nucleophiles, lithium tert-butoxide as the base, and iodine to mediate carbon-nitrogen bond formation. This method proceeds at room temperature under an air atmosphere using a normal benchtop set-up, or can be performed conveniently using microwave irradiation. Georg Thieme Verlag Stuttgart - New York.

Microwave-assisted hydrogen peroxide-mediated synthesis of benzoxazoles and related heterocycles via cyclodesulfurization

A novel approach has been developed to construct benzoxazoles and similar N- and S-containing heterocycles from their corresponding isothiocyanates and o-substituted anilines via cyclodesulfurization. The reaction was found to proceed via in situ formatio

Electrochemical NaI/NaCl-mediated one-pot synthesis of 2-aminobenzoxazoles in aqueous mediaviatandem addition-cyclization

An electrochemical synthesis of 2-aminobenzoxazoles from 2-aminophenols and isothiocyanates was successfully developed in a one-pot fashion. Using inexpensive and widely available NaI and NaCl co-operatively in catalytic amounts, our electrosynthesis approach provided various 2-aminobenzoxazole products in moderate to high yields in an open-flask type undivided cell without using any external supporting electrolyte and base. The protocol can be applied to the synthesis of 2-aminobenzothiazoles from the corresponding 2-thiophenols in moderate yields. This protocol has many benefits. It is metal-free and highly scalable and uses inexpensive mediators and EtOH/water as an environmentally friendly solvent under mild conditions.