1045823-02-6

Basic information

• Product Name: 3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester
• Synonyms: 3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester
• CAS NO: 1045823-02-6
• Molecular Weight: 275.251
• Mol File: 1045823-02-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester(1045823-02-6)
• EPA Substance Registry System: 3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester(1045823-02-6)

Safety Data

• Hazardous Substances Data: 1045823-02-6(Hazardous Substances Data)

Upstream product

• 2926-29-6 Langlois reagent 
• 1011-65-0 5-methoxycarbonylindole 

Relevant articles and documents

Transition-metal-free direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2

A novel transition metal-free route for the direct trifluoromethylthiolation of electron-rich aromatics using CF3SO2Na in the presence of PhPCl2 was developed. More specifically, PhPCl2 was used as both a reducing and a chlorinating reagent for the first time in this CF3SO2Na-based trifluoromethylthiolation reaction. The absence of transition metals and the use of cheap and readily available reagents render this method an alternative and practical strategy for the trifluoromethylthiolation of electron-rich aromatics.

Transition-Metal-Free Direct Trifluoromethylthiolation and Trifluoromethylsulfoxidation of Electron-Rich Aromatics with CF3SO2Na in the Presence of PCl3

A new transition-metal-free route for the direct trifluoromethylthiolation and trifluoromethylsulfoxidation of electron-rich aromatics with CF3SO2Na in the presence of PCl3 was developed. Notably, PCl3 was used as a reducing and chlorination reagent. The transition-metal-free protocol utilized cheap and readily available reagents and exhibited good atom economy; therefore, it will serve as an alternative and practical strategy for the trifluoromethylthiolation and trifluoromethylsulfoxidation of electron-rich aromatics.