1046-56-6 Usage
Description
3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine (PDT) is a yellow powder that is known for its chemical reactivity with certain metal ions, particularly Cu(II) perchlorate in ethanol, resulting in the formation of [Cu(PDT)2(ClO4)2]. This property makes it a valuable compound in analytical chemistry for the detection and quantification of specific elements.
Uses
Used in Analytical Chemistry:
3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine is used as a chromogenic-extraction reagent for the spectrophotometric determination of iron in acids and acidic solutions. Its ability to react with iron ions allows for the development of a color change that can be measured and correlated to the concentration of iron present in the sample.
Additionally, 3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine is used as a precolumn derivatizing reagent in the High-Performance Liquid Chromatography (HPLC) method with UV absorbance detection for the determination of Fe(II). This application takes advantage of PDT's reactivity with Fe(II) to form a derivative that can be separated and detected using HPLC, providing a sensitive and accurate method for Fe(II) analysis.
Indications
PDT with 20% ALA may be used for the treatment of actinic keratoses. The product is marketed as Levulan Kerastick (DUSA Pharmaceuticals, Valhalla, New York). The ALA is applied diffusely over the field with an applicator; the patient returns 1 to 3 hours later and is exposed to an activating light source. Once exposed to the light, ALA produces singlet oxygen, which damages the cell membrane. Sixty-six percent of patients had total clearing of lesions at 8 weeks using blue light exposure for 15 minutes. Patients experience a burning pain but heal with an excellent cosmetic result. Photosensitivity lasts for 24 hours. An optional regimen is to apply ALA only to visible actinic keratoses; however, this method will not treat subclinical lesions. A variety of lasers and light sources can be used to activate the ALA, including blue light, yellow light, and broadband light; however, many details remain to be worked out, such as the optimal incubation times for the ALA when using each of the various light sources.
Purification Methods
Purify it by repeated recrystallisation from EtOH/dimethylformamide. It is a reagent for estimating Fe(II) and Ru(II). [Chriswell & Schilt Anal Chem 46 992 1974, Kamra & Ayers Anal Chem 78 423 1975.]
Check Digit Verification of cas no
The CAS Registry Mumber 1046-56-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,4 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1046-56:
(6*1)+(5*0)+(4*4)+(3*6)+(2*5)+(1*6)=56
56 % 10 = 6
So 1046-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H14N4/c1-3-9-15(10-4-1)18-19(16-11-5-2-6-12-16)23-24-20(22-18)17-13-7-8-14-21-17/h1-14H
1046-56-6Relevant articles and documents
Broadening the scope of 1,2,4-triazine synthesis by the application of microwave technology
Zhao, Zhijian,Leister, William H.,Strauss, Kimberly A.,Wisnoski, David D.,Lindsley, Craig W.
, p. 1123 - 1127 (2003)
By the application of microwave technology, a general protocol has been developed for the rapid synthesis of diverse 3,5,6-trisubstituted 1,2,4-triazines in excellent yield and purity, including many previously unknown 3-heterocyclic-1,2,4-triazines.
Efficient Preparation of Pyridinyl-1,2,4-Triazines via Telescoped Condensation with Diversely Functionalized 1,2-Dicarbonyls
Tai, Serene,Marchi, Sydney V.,Carrick, Jesse D.
, p. 1138 - 1146 (2016/07/29)
The development of materials for efficient chemoselective extraction of minor actinides remains at the forefront of research efforts in the area of separation science. Lewis basic complexants derived from nitrogen-donor scaffolds are often employed in this area due to favorable complexation with the transuranic element americium. In the present work an efficient procedure for the preparation of eight useful 3-pyridin-2-yl-1,2,4-triazines (2 novel) is demonstrated via telescoped condensation with the requisite 1,2-dicarbonyl in two-pots without additives, differentially extractive work-up procedures, or recrystallization. Additional efforts in this area have demonstrated the utility of polar aprotic solvents for the preparation of nine functionalized pyridinyl-2,6-bis-1,2,4-triazines (4 novel) directly from the requisite 2,6-pyridine dicarbonitrile in 49–99% yield over four total steps. The streamlined preparation of these important materials and detailed synthetic procedures is reported herein.
Ferroin reagent
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, (2008/06/13)
3-(2-pyridyl)-5,6-bis(phenylsulfonic acid)-1,2,4-triazine and certain salts thereof, e.g.--sodium, are provided together with a method for forming such compounds. These compounds are useful as reagents in the spectrophotometric determination of iron in water or other solutions.
