104636-99-9

Basic information

• Product Name: 2-(1H-indol-2-ylcarbonyl)-5-methyl-2,3,4,7-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one
• CAS NO: 104636-99-9
• Molecular Formula: C₂₁H₁₇N₃O₂
• Molecular Weight: 343.3786
• Mol File: 104636-99-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 686.3°C at 760 mmHg
• Flash Point: 368.9°C
• Density: 1.61g/cm³
• Vapor Pressure: 1.1E-18mmHg at 25°C
• Refractive Index: 1.853
• CAS DataBase Reference: 2-(1H-indol-2-ylcarbonyl)-5-methyl-2,3,4,7-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-indol-2-ylcarbonyl)-5-methyl-2,3,4,7-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one(104636-99-9)
• EPA Substance Registry System: 2-(1H-indol-2-ylcarbonyl)-5-methyl-2,3,4,7-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one(104636-99-9)

Safety Data

• Hazardous Substances Data: 104636-99-9(Hazardous Substances Data)

Upstream product

• 127943-67-3 (R)-6-(1H-indol-2-ylcarbonyl)-8-(chloromethyl)-3,6,7,8-tetrahydro-1-methylbenzo<1,2-b:4,3-b'>dipyrrol-4-ol 
• 1477-50-5 Indole-2-carboxylic acid 
• 122330-65-8 ((R)-5-Benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol 
• 114996-71-3 (1R)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole 
• 108867-95-4 ((R)-5-Benzyloxy-3-methanesulfonyl-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol 
• 112836-68-7 (R)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo<1,2-b:4,3-b'>dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester 
• 112764-69-9 (R)-1-(chloromethyl)-1,6-dihydro-8-methyl-5-(phenylmethoxy)-benzo<1,2-b:4,3-b'>dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester 
• 112764-70-2 (R)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole 
• 110314-49-3 (R)-5-Benzyloxy-1-methanesulfonyloxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carboxylic acid tert-butyl ester 
• 58881-45-1 Indole-2-carbonyl chloride 
• 91534-38-2 1,2,8,8a-tetrahydro-7-methylcyclopropapyrrolo<3,2-e>indol-4-(5H)-one 
• 112089-90-4 Methanesulfonic acid 5-benzyloxy-3-(1H-indole-2-carbonyl)-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 
• 91534-32-6 ethyl 3,6-dihydro-5-hydroxy-8-methyl-6-(phenylsulfonyl)benzo<1,2-b:4,3-b'>dipyrrole-1-carboxylate 
• 91534-35-9 3-acetyl-1,2,3,6-tetrahydro-5-hydroxy-1-hydroxymethyl-8-methyl-6-phenylsulphonylpyrrolo<3,2-e>indole 

Relevant articles and documents

Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogues

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Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Unprotected Cyclopropapyrroloindole A Portion Using the 3,3'-Bipyrrole Strategy

The total synthesis of the unprotected A portion of the potent cytotoxic agent CC-1065 1 using the 3,3'-bipyrrole strategy is described.Treatment of ethyl sorbate with (p-tolylsulfonyl)methyl isocyanide (TosMIC)/NaH gave the pyrrole 7, which was N'-phenyl