104655-82-5

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-propenyl bis(1-methylethyl)phosphoramidite]
• CAS NO: 104655-82-5
• Molecular Formula: C40H50N3O8P
• Molecular Weight: 731.826
• Mol File: 104655-82-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-propenyl bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-propenyl bis(1-methylethyl)phosphoramidite](104655-82-5)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-propenyl bis(1-methylethyl)phosphoramidite](104655-82-5)

Safety Data

• Hazardous Substances Data: 104655-82-5(Hazardous Substances Data)

Upstream product

• 108-18-9 diisopropylamine 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 107-18-6 allyl alcohol 
• 108554-72-9 (allyloxy)bis(diisopropylamino)phosphine 

Downstream Products

• 104684-77-7 C₃₄H₃₇N₂O₉P 
• 183378-42-9 allyl [5'-O-(p,p'-dimethoxytrityl)thymidylyl]-(3'-5')-3'-O-[(allyloxy)carbonyl]thymidine 
• 77534-66-8 diisopropylammonium trifluoromethanesulfonate 
• 183378-45-2 C₄₁H₄₁N₄O₈P 
• 183378-48-5 C₄₀H₄₅N₄PO₁₁(CO₂C₃H₄)2 
• 361447-92-9 C₅₀H₆₃N₄O₁₄PSi 
• 50571-26-1 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 

Relevant articles and documents

Allyl as internucleotide protecting group in DNA synthesis to be cleaved off by ammonia

Deprotection of allyl groups from internucleotide phosphotriester functions can be achieved not only with Pd0-mediated cleavage in the presence of an appropriate nucleophile but also under standard conditions for DNA fragments using conc. ammon

A NEW AND VERSATILE APPROACH TO THE PREPARATION OF VALUABLE DEOXYNUCLEOSIDE 3'-PHOSPHITE INTERMEDIATES

The easily accessible and crystalline monofunctional phosphitylating reagent bis-(diisopropylamino)chlorophosphine has been used for the synthesis of phosphoramidites and H-phosphonates of d-nucleosides and, also, the formation of 3'-5'-internucleotidic phosphonate bonds.