1046828-46-9

Basic information

• Product Name: C₂₇H₃₈N₂O₂Si
• CAS NO: 1046828-46-9
• Molecular Weight: 450.696
• Mol File: 1046828-46-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₈N₂O₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₈N₂O₂Si(1046828-46-9)
• EPA Substance Registry System: C₂₇H₃₈N₂O₂Si(1046828-46-9)

Safety Data

• Hazardous Substances Data: 1046828-46-9(Hazardous Substances Data)

Upstream product

• 1046828-40-3 1-(tert-butyldimethylsilyl)-5-methyl-1H-indole 
• 177896-09-2 tert-butyl benzylidenecarbamate 

Relevant articles and documents

Chiral phosphoric acid-catalyzed enantioselective aza-Friedel-Crafts reaction of indoles

A highly enantioselective 1,2-aza-Friedel-Crafts reaction of N-tert-butyldimethylsilylindole with N-tert-butoxycarbonyl aromatic imines is demonstrated using a BINOL-derived monophosphoric acid catalyst. The present approach provides efficient access to 3-indolylmethaneamines with aryl substituents in excellent enantioselectivities (up to 98% ee). An inversion in the sense of enantioselection was found between monophosphoric acid catalysts bearing different substituents introduced at the 3,3′-position of binaphthyl backbone. We also calculated the three-dimensional structure of the monophosphoric acid catalysts to speculate on the inversion of the stereochemical outcome.