104683-00-3

Basic information

• Product Name: N-(4-methyl-2-(phenylethynyl)phenyl)acetamide
• Synonyms: N-(4-methyl-2-(phenylethynyl)phenyl)acetamide
• CAS NO: 104683-00-3
• Molecular Weight: 249.312
• Mol File: 104683-00-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-methyl-2-(phenylethynyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methyl-2-(phenylethynyl)phenyl)acetamide(104683-00-3)
• EPA Substance Registry System: N-(4-methyl-2-(phenylethynyl)phenyl)acetamide(104683-00-3)

Safety Data

• Hazardous Substances Data: 104683-00-3(Hazardous Substances Data)

Upstream product

• 13141-44-1 4-methyl-2-(phenylethynyl)aniline 
• 108-24-7 acetic anhydride 
• 536-74-3 phenylacetylene 
• 29289-13-2 2-iodo-4-methylaniline 
• 29289-16-5 N-(2-iodo-4-methylphenyl)acetamide 
• 1241049-33-1 C₁₇H₁₅NO 
• 614-83-5 2-bromo-4-methylacetanilide 
• 3757-88-8 tributylstannylethynylbenzene 
• 13146-23-1 copper(I) phenylacetylenide 
• 101010-07-5 C₁₃H₁₀F₆NO₅Tl 

Downstream Products

• 1241049-21-7 1-(3-chloro-5-methyl-2-phenyl-1H-indol-1-yl)ethanone 
• 13228-36-9 5-methyl-2-phenyl-1H-indole 
• 104683-04-7 1-(5-methyl-2-phenyl-1H-indol-1-yl)ethan-1-one 

Relevant articles and documents

Nickel-Catalyzed Arylative Additions on 2-Alkynyl-N-Arylsulfonylanilides to Construct Functionalized Indoles

The addition of aryl iodides to 2-alkynyl-N-sulfonylanilides to form 2,3-difunctionalized N-arylsulfonylindoles can be catalyzed using a nickel catalyst ligated to a bis(cyclohexanyl)phosphinoferrocene. A variety of nickel complexes can be used as precata

Multicatalytic one-pot reaction of 1-(2-alkynylphenyl)ketoximes for generation of indole derivatives

Multicatalytic one-pot Beckmann rearrangement/intramolecular cyclization/halogenation reaction of 1-(2-alkynylphenyl)ketoxime is reported, leading to the expected indole derivatives in good yield.

THALLIUM IN ORGANIC SYNTHESIS. 68. A CONVENIENT SYNTHESIS OF 2-PHENYLINDOLES FROM ANILIDES

Thallation of anilides with TTFA in a mixture of TFA and ether gives ortho-thallated derivatives, which yield 2-acetamidotolanes upon reaction with copper (I) phenylacetylide in acetonitrile.Treatment of the latter compounds with palladium(II) chloride results in ring closure to give 1-acyl-2-phenylindoles, from which 2-phenylindoles are obtained by alkaline hidrolysis.