104685-76-9

Basic information

• Product Name: 5,6-DIAMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5,6-DIAMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;5,6-DiaMinopyidine-3-carboxxylic acid Methyl ester;Methyl 5,6-diaMinonicotinate;5,6-Diamino-nicotinic acid methyl ester
• CAS NO: 104685-76-9
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.167
• Mol File: 104685-76-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,6-DIAMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIAMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER(104685-76-9)
• EPA Substance Registry System: 5,6-DIAMINOPYRIDINE-3-CARBOXYLIC ACID METHYL ESTER(104685-76-9)

Safety Data

• Hazardous Substances Data: 104685-76-9(Hazardous Substances Data)

Usage

General Description

5,6-Diaminopyridine-3-carboxylic acid methyl ester, also known as DAPME, is a chemical compound primarily used in the pharmaceutical industry as an intermediate or building block for the synthesis of various drugs. It is a methyl ester derivative of 5,6-diaminopyridine-3-carboxylic acid, which is a heterocyclic compound containing both amino and carboxylic acid functional groups. DAPME is known for its potential as a precursor in the development of antiviral and antitumor agents. It has also been studied for its potential therapeutic uses in the treatment of neurological disorders and muscle weakness. However, DAPME is primarily used as an intermediate in the synthesis of other compounds and is not widely available for commercial use in its pure form. It is important to handle DAPME with proper safety measures due to its potential hazards and toxicity.

Upstream product

• 104685-75-8 methyl 2-amino-3-nitropyridine-5-carboxylate 
• 267875-45-6 5,6-diamino-nicotinic acid 
• 24242-19-1 5-aminonicotinic acid 
• 1354975-98-6 5-amino-6-nitropyridine-3-carboxylic acid 
• 1354975-99-7 methyl 5-amino-6-nitropyridine-3-carboxylate 
• 59237-53-5 methyl 6-chloro-5-nitro-pyridine-3-carboxylate 

Downstream Products

• 77862-95-4 methyl 3H-imidazo[4,5-b]pyridine-6-carboxylate 
• 122771-62-4 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine 
• 675200-33-6 6-Amino-5-(4-nitro-benzoylamino)-nicotinic acid methyl ester 
• 248919-96-2 8-amino-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 

Relevant articles and documents

Mild and efficient addition of carbon nucleophiles to condensed pyridines: influence of structure and limits of applicability

[Figure not available: see fulltext.] A number of azolo- and azinopyridines with varying substituents and annulated heterocycles were synthesized and examined in dearomatization reactions with carbon nucleophiles. Depending on the structure, the resulting covalent σ-adducts were formed either under basefree conditions or in Et3N-promoted process to give functionalized condensed dihydropyridines. Quantum-chemical calculations of the global electrophilicity index derived from FMO energies of azolopyridine series were performed to explain reactivity toward neutral and anionic C-nucleophiles. These values may be useful for qualitative prediction of particular reactivity pattern.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS

Disclosed is a compound of Formula I or a salt thereof, in which X, X1, X2, R1, R2, and R3 are described herein. Also disclosed are pharmaceutical compositions and methods of using the compounds of Formula I to treat disorders mediated by melanocortin-4 r