104690-41-7

Basic information

• Product Name: 5-(4-fluorophenyl)-1,2,4-triazolo<1,5-a>pyrimidin-7-ol
• Synonyms: 5-(4-fluorophenyl)-1,2,4-triazolo<1,5-a>pyrimidin-7-ol
• CAS NO: 104690-41-7
• Molecular Weight: 230.201
• Mol File: 104690-41-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-1,2,4-triazolo<1,5-a>pyrimidin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-1,2,4-triazolo<1,5-a>pyrimidin-7-ol(104690-41-7)
• EPA Substance Registry System: 5-(4-fluorophenyl)-1,2,4-triazolo<1,5-a>pyrimidin-7-ol(104690-41-7)

Safety Data

• Hazardous Substances Data: 104690-41-7(Hazardous Substances Data)

Upstream product

• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 61-82-5 3-amino-1,2,4-triazole 
• 95095-77-5 2,3-Diamino-6-(4-fluoro-phenyl)-3H-pyrimidin-4-one 
• 122-51-0 orthoformic acid triethyl ester 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 

Downstream Products

• 104690-23-5 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[5-(4-fluoro-phenyl)-7-oxo-7H-[1,2,4]triazolo[1,5-a]pyrimidin-3-yl]-tetrahydro-furan-3-yl ester 
• 104690-16-6 3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 

Relevant articles and documents

The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents

We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the scaffold were examined rationally to establish a structure-activity relationship with the goal of improving potency and maintaining good physicochemical properties. A number of compounds displayed sub-micromolar activity against Mycobacterium tuberculosis with no cytotoxicity against eukaryotic cells. Non-substituted aromatic rings at C5 and a two-carbon chain connecting a terminal aromatic at C7 were preferred features; the presence of NH at C7 and a lack of substituent at C2 were essential for potency. We identified compounds with acceptable metabolic stability in rodent and human liver microsomes. Our findings suggest that the easily-synthesized triazolopyrimidines are a promising class of potent anti-tubercular agents and warrant further investigation in our search for new drugs to fight tuberculosis.