104773-40-2

Basic information

• Product Name: (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester
• Synonyms: (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester;4-nitrobenzyl (2S,4S)-4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• CAS NO: 104773-40-2
• Molecular Formula: C₁₅H₁₈N₂O₆S
• Molecular Weight: 354.37822
• EINECS: 1533716-785-6
• Mol File: 104773-40-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.41
• CAS DataBase Reference: (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(104773-40-2)
• EPA Substance Registry System: (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(104773-40-2)

Safety Data

• Hazardous Substances Data: 104773-40-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester" is a complex molecule with multiple functional groups. It is a derivative of pyrrolidinecarboxylic acid and contains an acetylthio group, a hydroxymethyl group, and a 4-nitrophenylmethyl ester moiety. The compound has a stereocenter at the 2nd and 4th positions, and the (2S,4S) configuration indicates the absolute stereochemistry of the molecule. This chemical may have potential applications in pharmaceutical research or organic synthesis due to its unique structure and functional groups.

Upstream product

• 127626-37-3 (2S,4R)-2-hydroxymethyl-4-methanesulfonyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 10387-40-3 potassium thioacetate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 101803-29-6 (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 51-35-4 4R-4-hydroxyproline 
• 138324-82-0 (2S,4R)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 96034-57-0 (2S,4R)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 101803-42-3 (2S,4S)-4-mercapto-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 104795-24-6 (2S,4S)-1-(p-nitrobenzyloxycarbonyl)-2-ethoxycarbonyloxymethyl-4-acetylthiopyrrolidine 
• 127190-98-1 (2S,4S)-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)-4-(triphenylmethylthio)pyrrolidine 
• 104772-90-9 (2S,4S)-1-(p-nitrobenzyloxycarbonyl)-2-acetoxymethyl-4-acetylthiopyrrolidine 
• 104773-41-3 (2S,4S)-1-(p-nitrobenzyloxycarbonyl)-2-trichloroacetylaminocarbonyloxymethyl-4-acetylthiopyrrolidine 
• 491878-06-9 (2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester 

Relevant articles and documents

Synthesis and?antibacterial activities of?new 1β-methylcarbapenems having aminopyrimidinylthioether moiety

The synthesis of new 1β-methylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I).

Carbapenem compounds and production thereof

A compound of the formula: STR1 wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxycarbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: STR2 wherein R3 and R4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group, wherein Z represents --NH-- or --O-- and R5 represents an amino group, a mono(lower)alkylamino group, a di(lower)alkylamino group, a lower alkyloxy group or a lower alkyl group, STR3 wherein R6 represents a hydrogen atom or a lower alkyl group, wherein R7 represents a mono(lower)alkylamino group, a di(lower)alkylamino group or a lower alkyloxy group, or STR4 wherein R8, R9 and R10, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, Y represents a hydrogen atom, a conventinal protecting group for an amino group or a group of either one of the following formulas: STR5 wherein R11 and R12, which may be the same or different, each represents a hydrogen atom or a lower alkyl group or STR6 wherein R6 is as defined above and n is an ingeter of 1 to 6, and a pharmacologically acceptable salt thereof, which is useful as an antimicrobial agent.