104783-89-3

Basic information

• Product Name: 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone
• Synonyms: 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone
• CAS NO: 104783-89-3
• Molecular Weight: 242.296
• Mol File: 104783-89-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone(104783-89-3)
• EPA Substance Registry System: 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone(104783-89-3)

Safety Data

• Hazardous Substances Data: 104783-89-3(Hazardous Substances Data)

Upstream product

• 21855-46-9 ethyl 3,5-dibromo-2,4-dihydroxy-6-methyl benzoate 
• 2524-37-0 ethyl orselinate 
• 6110-36-7 ethyl everninate 
• 67-68-5 dimethyl sulfoxide 

Relevant articles and documents

Mushroom tyrosinase inhibition activity of some chromones

Currently, aloesin is used in the cosmetic industry as a whitening agent because it inhibits tyrosinase activity. Aloesin is a C-glycosylated chromone compound isolated from aloe, and it is difficult to synthesize because of C-glycosyl moiety in the molecule. The purpose of this study is to search for a new chromone compound which is easy to synthesize and which posesses stronger tyrosinase inhibitory activity than aloesin. Fourteen chromone derivatives were synthesized and screened for their mushroom-tyrosinase inhibitory activity. 5-Methyl-7-methoxy-2-(2′-benzyl-3′-oxobutyl)chromone (15) showed the strongest activity among tested compounds. Its activity was not only stronger than aloesin, but also stronger than arbutin and kojic acid. The kinetic analysis revealed a competitive inhibition of 15 with tyrosinase for the L-tyrosine binding site.