104785-90-2

Basic information

• Product Name: 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester
• Synonyms: 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester
• CAS NO: 104785-90-2
• Molecular Weight: 246.222
• Mol File: 104785-90-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester(104785-90-2)
• EPA Substance Registry System: 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester(104785-90-2)

Safety Data

• Hazardous Substances Data: 104785-90-2(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 32863-32-4 benzo[c][1,2,5]oxadiazole-4-carbaldehyde 

Downstream Products

• 75695-93-1 isradipine 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE MANUFACTURE OF ISRADIPINE.

The present invention relates to an improved method for the manufacture of Isradipine, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester. which, involves reacting 2,1,3-benzoxadiazole-4-carboxaldehyde with methyl acetoacetate in the presence of acetic acid and piperidine in diisopropyl ether. To obtain the product 2-acetyl-3-benzofurazan-4-yl-acrylic acid methyl ester which is then reacted with isopropyl-?-aminocrotonate in ethanol at 25 to 35°C to obtain the product.