104873-98-5

Basic information

• Product Name: (3S)-3-METHYL-1,4-BENZODIAZEPINE-2,5-DIONE
• Synonyms: (3S)-3-METHYL-1,4-BENZODIAZEPINE-2,5-DIONE;3-Methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione;3-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-quinone;(3S)-3-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione
• CAS NO: 104873-98-5
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Product Categories: pharmacetical
• Mol File: 104873-98-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 510.2°Cat760mmHg
• Flash Point: 238.5°C
• Appearance: /
• Density: 1.195g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: (3S)-3-METHYL-1,4-BENZODIAZEPINE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3-METHYL-1,4-BENZODIAZEPINE-2,5-DIONE(104873-98-5)
• EPA Substance Registry System: (3S)-3-METHYL-1,4-BENZODIAZEPINE-2,5-DIONE(104873-98-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 104873-98-5(Hazardous Substances Data)

Usage

General Description

(3S)-3-Methyl-1,4-benzodiazepine-2,5-dione is a chemical compound belonging to the benzodiazepine class of drugs. It is a potent sedative and anxiolytic agent, and is commonly used as a prescription medication to treat anxiety, insomnia, and other related disorders. Its mechanism of action involves enhancing the inhibitory signaling of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, resulting in a calming effect on the central nervous system. Due to its potential for abuse and dependency, it is classified as a controlled substance in many countries and should only be used under the supervision of a healthcare professional.

InChI:InChI=1/C10H10N2O2/c1-6-9(13)12-8-5-3-2-4-7(8)10(14)11-6/h2-6H,1H3,(H,11,14)(H,12,13)/t6-/m0/s1

Upstream product

• 68790-38-5 2-(tert-butyloxycarbonylamino)benzoic acid 
• 2224-52-4 L-alanine N-carboxyanhydride 
• 769120-97-0 (S)-2-(2-Amino-benzoylamino)-propionic acid ethyl ester 
• 118-48-9 isatoic anhydride 
• 1115-59-9 (S)-alanine ethyl ester hydrochloride 
• 34897-85-3 o-azidobenzoyl chloride 
• 56-41-7 L-alanin 
• 14683-53-5 2-amine-N-[(S)-methoxycarbonylethyl]benzamide 

Relevant articles and documents

Improved method for microwave-assisted synthesis of benzodiazepine-2,5-diones from isatoic anhydrides mediated by glacial acetic acid

An improved and simpler method for the synthesis of benzodiazepin-2,5-diones and 7-iodobenzodiazepin-2,5-diones catalyzed by glacial acetic acid using isatoic anhydride and 6-iodoisatoic anhydride, respectively, as starting materials is reported. The target products were achieved in good yields (up to 71percent) using microwave irradiation as the activating mode of reaction in the presence of acetic acid instead of the traditional polar aprotic solvents as dimethylformamide (DMF), dimethyl sulfoxide (DMSO) or dimethylacetamide (DMAC). Moreover, relatively simple purification workup is required. The optimal temperature to obtain the benzodiazepin-2,5-dione derivatives was 130 °C, while the best irradiation time was 3 min. In addition, the methodology for the selective preparation of 6-iodoisatoic anhydride with an overall yield of 62percent is presented. Printed in Brazil-

Facile synthesis of 1,4-benzodiazepine-2,5-diones and quinazolinones from amino acids as anti-tubercular agents

A family of 1,4-benzodiazepine-2,5-diones and quinazolinones with diverse substituents at the C-3 position were synthesized via a novel, simple and convenient methodology using H2PtCl6 as the catalyst. The substitution at the C-3 pos

Identification of the benzodiazepines as a new class of antileishmanial agent

The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have ident