1048958-14-0

Basic information

• Product Name: 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1048958-14-0
• Molecular Weight: 315.415
• Mol File: 1048958-14-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline(1048958-14-0)
• EPA Substance Registry System: 1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline(1048958-14-0)

Safety Data

• Hazardous Substances Data: 1048958-14-0(Hazardous Substances Data)

Upstream product

• 78317-83-6 2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 100-59-4 phenylmagnesium chloride 
• 100-58-3 phenylmagnesium bromide 
• 98-80-6 phenylboronic acid 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 55662-90-3 2-(4-methoxyphenyl)-3,4-dihydroisoquinolinium bromide 
• 1078-58-6 diphenylzinc 
• 23665-09-0 phenylzinc iodide 
• 38111-44-3 phenylzinc(II) bromide 
• 16002-63-4 phenylmagnesium iodide 

Downstream Products

• 1582284-73-8 1-(4-tolyl)-1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1582284-70-5 1-methyl-1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1582284-71-6 1-ethyl-1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1582284-72-7 1-isopropyl-1-phenyl-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Photo-induced sp3 C?H bond arylation, cyanation and nitroalkylation of tetrahydroisoquinolines (THIQs) under visible light irradiation using a combination of NHPI and Rose Bengal

This work reports a sustainable protocol for α-arylation of tetrahydroisoquinolines (THIQs) with aryl diazonium salts using a combination of a cheap and stable oxidant, N-hydroxyphthalimide (NHPI), and an inexpensive dye photosensitizer, Rose Bengal (RB),

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates

Nucleophilic trapping of iminium salts generated via oxidative functionalisation of tertiary amines is well established with stabilised carbon nucleophiles. The few reports of organometallic additions have limited scope of substrate and organometallic nucleophile. We report a novel, one-pot methodology that functionalises N - substituted tetrahydroisoquinolines by visible lightassisted photooxidation, followed by trapping of the resultant iminium ions with organometallic nucleophiles. This affords 1,2-disubstituted tetrahydroisoquinolines in moderate to excellent yields.

Simple and direct sp3 C-H bond arylation of tetrahydroisoquinolines and isochromans via 2,3-dichloro-5,6-dicyano-1,4- benzoquinone oxidation under mild conditions

The 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated sp3 C-H bond arylation of tetrahydroisoquinolines and isochromans is described. The corresponding products were facilely synthesized via a simple nucleophilic addition reaction betwee