104902-94-5 Usage
Description
1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)-, also known as 1-(2,3-Dihydro-1H-indol-1-yl)prop-2-en-1-one, is an organic compound that serves as a key intermediate in the synthesis of acrylamide-functionalized indolines and indoles. These synthesized compounds have potential applications as mTORC1 modulators, which are significant in the treatment of various diseases, including cancer, neurodegenerative, and metabolic disorders.
Uses
Used in Pharmaceutical Industry:
1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)is used as a chemical intermediate for the preparation of acrylamide-functionalized indolines and indoles. These compounds act as mTORC1 modulators, which are crucial in the development of therapeutic agents for the treatment of cancer, neurodegenerative, and metabolic diseases. The modulation of mTORC1 pathways can help regulate cellular processes and offer potential therapeutic benefits in managing these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 104902-94-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,0 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 104902-94:
(8*1)+(7*0)+(6*4)+(5*9)+(4*0)+(3*2)+(2*9)+(1*4)=105
105 % 10 = 5
So 104902-94-5 is a valid CAS Registry Number.
104902-94-5Relevant articles and documents
Total synthesis of (±)-mersicarpine
Magolan, Jakob,Carson, Cheryl A.,Kerr, Michael A.
, p. 1437 - 1440 (2008)
(Chemical Equation Presented) The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a β-dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish the masked 1,2-dicarbonyl functionality. An X-ray crystal structure and discussion of the 1H NMR behavior of the natural product are also presented.
mTORC1 MODULATORS
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Paragraph 0596-0598; 0602; 0620-0621, (2019/04/30)
Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.
COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4
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Paragraph 0645; 0647; 0682, (2018/08/26)
Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).