10496-75-0

Basic information

• Product Name: 2-methoxy-5-nitrobenzonitrile
• Synonyms: 2-methoxy-5-nitrobenzonitrile;2-Cyano-4-nitroanisole;Einecs 234-027-6;Benzonitrile, 2-methoxy-5-nitro-
• CAS NO: 10496-75-0
• Molecular Formula: C₈H₆N₂O₃
• Molecular Weight: 178.14484
• EINECS: 234-027-6
• Mol File: 10496-75-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 339°Cat760mmHg
• Flash Point: 158.8°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 9.44E-05mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-methoxy-5-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-5-nitrobenzonitrile(10496-75-0)
• EPA Substance Registry System: 2-methoxy-5-nitrobenzonitrile(10496-75-0)

Safety Data

• Hazardous Substances Data: 10496-75-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 88, p. 2884, 1966 DOI: 10.1021/ja00964a070

InChI:InChI=1/C8H6N2O3/c1-13-8-3-2-7(10(11)12)4-6(8)5-9/h2-4H,1H3

Upstream product

• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 124-41-4 sodium methylate 
• 134604-07-2 2-bromo-5-nitrobenzonitrile 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 709-09-1 3,4-dimethoxynitrobenzene 
• 151-50-8 potassium cyanide 
• 2112-24-5 2,5-Dinitrobenzonitrile 
• 127839-39-8 2-methoxy-5-nitrophenylchlorodinitromethane 
• 140-29-4 phenylacetonitrile 
• 75-05-8 acetonitrile 
• 119-27-7 2,4-dinitroanisole 
• 13435-20-6 tetraethylammoniumcyanide 
• 455-93-6 2-fluoro-1-methoxy-4-nitrobenzene 
• 143-33-9 sodium cyanide 

Downstream Products

• 19019-04-6 2-Methoxy-3,5-dinitrobenzonitrile 
• 59263-62-6 2-methoxy-5-nitro-benzamide 
• 214623-57-1 5-amino-2-methoxybenzyl cyanide 
• 96-97-9 5-nitrosalicylic acid 
• 40751-89-1 2-methoxy-5-nitrobenzoic acid 
• 22603-53-8 1-amino-2-cyano-4,6-dinitrobenzene 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 51073-04-2 (2-methoxy-5-nitro-phenyl)-acetic acid 
• 79352-75-3 3-amino-6-methoxybenzylamine 
• 1431960-50-7 C₁₇H₁₉N₅OS 
• 1431959-21-5 N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-methoxyphenyl)acrylamide trifluoroacetate 
• 5804-49-9 2-methoxy-5-nitrophenylmethanol 
• 1254102-46-9 3-(((tert-butyldimethylsilyl)oxy)methyl)-4-methoxyaniline 
• 25016-02-8 2-methoxy-5-nitrobenzaldehyde 

Relevant articles and documents

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

1-substituted phenyl-1H-1,2,3-triazole compound as well as preparation method and application thereof

The invention relates to a 1-substituted phenyl-1H-1,2,3-triazole compound, in particular to a compound applicable to preparation of anti-gout drugs and a preparation method of the compound, and belongs to the field of medicines. The compound is as shown in the general formula, wherein each R1 is independent alkyl of 1-10 carbons, 3-10 carbon atom naphthenic bases, allyl, methoxy ethyl, benzyl and substituted benzyl; substituted benzyl can be p-halogenated benzyl, p-cyano benzyl and p-alkoxy benzyl; each R2 is independent H or methyl; each R3 is independent H or ethyl. Experimental results show that the compound has a good effect in the in-vitro xanthine oxidase inhibition activity test.