1049809-90-6

Basic information

• Product Name: (S)-4-(3-chloropropyl)-3-methylmorpholine
• Synonyms: (S)-4-(3-chloropropyl)-3-methylmorpholine
• CAS NO: 1049809-90-6
• Molecular Formula: C₈H₁₆ClNO
• Molecular Weight: 178
• Mol File: 1049809-90-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-4-(3-chloropropyl)-3-methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(3-chloropropyl)-3-methylmorpholine(1049809-90-6)
• EPA Substance Registry System: (S)-4-(3-chloropropyl)-3-methylmorpholine(1049809-90-6)

Safety Data

• Hazardous Substances Data: 1049809-90-6(Hazardous Substances Data)

Usage

General Description

(S)-4-(3-chloropropyl)-3-methylmorpholine is a chemical compound that consists of a morpholine ring with a 3-methyl group and a 3-chloropropyl group attached to it. It is a chiral molecule, meaning it has a non-superimposable mirror image, and exists in two enantiomeric forms denoted as (S)- and (R)-. (S)-4-(3-chloropropyl)-3-methylmorpholine has applications in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of surfactants and polymers. It is also used as a building block in organic synthesis to create a variety of different chemical structures. The chloropropyl group makes this compound reactive and useful for various chemical reactions, making it a valuable intermediate in the production of many different products.

Upstream product

• 350595-57-2 (S)-3-methylmorpholine 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1049809-93-9 2-{3-(4-chloro-3-iodo-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide 
• 1215171-56-4 C₂₅H₃₄ClIN₄O₃ 
• 1215171-57-5 C₂₅H₃₄ClIN₄O₃ 
• 1049811-59-7 2-(3-{4-Chloro-3-[(4-chloro-3-{[(phenylmethyl)amino]methyl}phenyl)ethynyl]phenyl}-1-{3-[(3S)-3-methylmorpholin-4-yl]propyl}-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)-2-oxoacetamide 
• 1049809-89-3 2-{3-(4-chloro-3-{4-[(4-chloro-benzylamino)-methyl]-phenylethynyl}-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide 
• 1181359-24-9 2-{3-(4-chloro-3-{4-[(4-chloro-benzylamino)-methyl]-phenylethynyl}-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide L-tartrate 

Relevant articles and documents

Practical synthesis of a cathepsin S Inhibitor: Route identification, purification strategies, and serendipitous discovery of a crystalline salt form

Chemical Equation Presented A redox economical strategy resulted in a concise, modular synthesis of compound 1, a potent Cathepsin S inhibitor. Starting from three building blocks, crude drug substance was prepared, in a two-step sequence in high yield. Efficient purification of the crude drug substance was accomplished via the formation of an unusual monoethyl oxalate salt.

CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S

Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.