105-41-9 Usage
Description
1,3-Dimethylpentylamine, also known as DMAA or methylhexanamine, is a synthetic pharmaceutical with a structure similar to ephedrine and adrenaline. It was patented in the 1940s as a nasal decongestant and has since been used as a recreational stimulant and a pre-workout supplement. Despite its status as a doping agent and concerns over its safety, DMAA has become a widely used ingredient in sports food supplements.
Uses
Used in Sports Supplements:
1,3-Dimethylpentylamine is used as a pre-workout stimulant for its ability to improve exercise performance and related variables. It is often combined with caffeine to enhance these effects.
Used in Dietary Supplements:
1,3-Dimethylpentylamine is used as a component in dietary supplements, where it aids in appetite suppression and provides a boost in energy and focus.
Used in Pharmaceutical Industry (Historic):
1,3-Dimethylpentylamine was historically used as a nasal decongestant, although no medical use of DMAA is recognized today.
It is important to note that the FDA has detained some products containing DMAA, such as Jack3d and OxyElite Pro, due to safety concerns. Additionally, the FDA is not aware of any reliable science indicating that DMAA exists naturally in plants.
Originator
Forthane,Lilly,US,1948
Manufacturing Process
One molecular equivalent of 4-methylhexanone-2 is reacted with slightly more than one molecular equivalent of hydroxylamine. Desirably, the hydroxylamine is prepared in the presence of the 4-methylhexanone-2 by reacting the hydrochloride or sulfate or other salt of the hydroxylamine with a suitable base, such as sodium carbonate or sodium hydroxide. Desirably, the reaction mixture is agitated for a few hours to insure the conversion of the 4- methylhexanone-2 to 4-methylhexanone-2 oxime.The resulting 4-methylhexanone-2 oxime separates and is dried by any
suitable means, such as with a dehydrating agent, for example, sodium
sulfate or magnesium sulfate. After drying, 4-methylhexanone-2 oxime is
reduced with hydrogen by means of a catalyst, such as Raney nickel, or by
reaction of sodium and a primary alcohol, such as ethanol. The resulting 2-
amino-4-methylhexane may be purified by distillation, as described in US
Patent 2,350,318.115 g (1 mol) of 2-amino-4-methylhexane and 9 g (0.5 mol) of water are
placed in a tared 500 cc 3-necked flask which is equipped with a mechanical
stirrer, a thermometer, and a gas delivery tube. The flask is surrounded by a
cooling bath of ice and water. Dry carbon dioxide gas is introduced into the
solution through the gas delivery tube, with constant stirring, until the
increase in weight is approximately 22 g (0.5 mol). The temperature during
this addition is maintained between 20° and 30°C. A viscous liquid results,
and consists essentially of 2-amino-4-methylhexane carbonate. This also
dissociates very slowly at room temperature to the free amine, carbon
dioxide, and water; and is effective as an inhalant, according to US Patent
2,386,273.
Therapeutic Function
Nasal decongestant
Check Digit Verification of cas no
The CAS Registry Mumber 105-41-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 105-41:
(5*1)+(4*0)+(3*5)+(2*4)+(1*1)=29
29 % 10 = 9
So 105-41-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H17N.ClH/c1-4-6(2)5-7(3)8;/h6-7H,4-5,8H2,1-3H3;1H