10500-64-8

Basic information

• Product Name: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol
• Synonyms: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol;4-(4'-Hydroxy-1'-Methyl-3,4-butylaMino)-7-chloroquinoline;4-((7-chloroquinolin-4-yl)amino)pentan-1-ol;Hydroxychloroquine sulfate Impurity E
• CAS NO: 10500-64-8
• Molecular Formula: C₁₄H₁₇ClN₂O
• Molecular Weight: 264.75058
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 10500-64-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 158-160°C
• Boiling Point: 453.7°C at 760 mmHg
• Flash Point: 228.2°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 5.08E-09mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.09±0.10(Predicted)
• CAS DataBase Reference: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol(10500-64-8)
• EPA Substance Registry System: 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol(10500-64-8)

Safety Data

• Hazardous Substances Data: 10500-64-8(Hazardous Substances Data)

Usage

Description

4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol is an organic compound with a chemical structure that features a pentanol backbone and a 7-chloro-4-quinolinyl amino group. It is a yellow solid, which indicates its stability and potential for use in various applications.

Uses

Used in Pharmaceutical Industry:
4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol is used as an intermediate in the preparation of Cletoquine Oxalate and Chloroquinolin. These compounds are known for their antimalarial properties and are used to treat and prevent malaria infections. The intermediate plays a crucial role in the synthesis of these drugs, contributing to their development and production.
Used in Chemical Synthesis:
As a chemical intermediate, 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol can be utilized in the synthesis of various other compounds with potential applications in different industries. Its unique structure allows for further chemical reactions and modifications, making it a versatile building block for the creation of new molecules with specific properties and uses.

InChI:InChI=1/C14H17ClN2O/c1-10(3-2-8-18)17-13-6-7-16-14-9-11(15)4-5-12(13)14/h4-7,9-10,18H,2-3,8H2,1H3,(H,16,17)

Upstream product

• 86-98-6 4,7-dichloroquinoline 
• 927-55-9 (±)-4-amino-1-pentanol 

Downstream Products

• 4298-15-1 Cletoquine 

Relevant articles and documents

Preparation method of hydroxychloroquine impurity

The invention discloses a preparation method of a hydroxychloroquine impurity. 4-amino-1-pentanol taken as a raw material undergoes a five-step reaction to realize synthesis of a hydroxychloroquine impurity VIII. The preparation method is reasonable in process design and high in operability, and industrial production can be realized; reagents used in the synthesis method are simple and easy to obtain; the purity of the hydroxychloroquine impurity obtained through the reaction can reach 98% or above, and the total yield can reach 20% or above. The hydroxychloroquine impurity prepared by the invention provides an important basis for scientific evaluation of quality, safety and efficiency of hydroxychloroquine.