105026-89-9

Basic information

• Product Name: N-(4-hydroxy-3-methoxybenzyl)benzamide
• Synonyms: N-(4-hydroxy-3-methoxybenzyl)benzamide
• CAS NO: 105026-89-9
• Molecular Weight: 257.289
• Mol File: 105026-89-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-hydroxy-3-methoxybenzyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxy-3-methoxybenzyl)benzamide(105026-89-9)
• EPA Substance Registry System: N-(4-hydroxy-3-methoxybenzyl)benzamide(105026-89-9)

Safety Data

• Hazardous Substances Data: 105026-89-9(Hazardous Substances Data)

Upstream product

• 1196-92-5 Vanillylamin 
• 98-88-4 benzoyl chloride 
• 7149-10-2 vanillylamine hydrochloride 
• 2874-33-1 vanillin oxime 
• 6282-02-6 N-(hydroxymethyl)benzamide 
• 90-05-1 2-methoxy-phenol 

Relevant articles and documents

Combined infrared spectroscopic and computational study on simpler capsaicin derivatives and their anion intermediates in the scavenging of free radicals

Two capsaicin analogues – N-(4-hydroxy-3-methoxybenzyl)acetamide and N-(4-hydroxy-3-methoxybenzyl)benzamide, were studied by DFT methods in order to estimate their ability to act as antioxidants. A comparative study on the stability of benzylic, phenoxyl and amide radicals has outlined the most reactive site for hydrogen atom abstraction and proton transfer. The enthalpies related to the formation of those species were modeled in gas phase, benzene, DMSO and water in order to determine the most probable mechanism of antioxidant action in polar and nonpolar medium. The formation of phenoxyl anion, energetically favoured in polar medium, was investigated by infrared spectroscopy methods based on the conversion of the benzamide derivative.

Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H2O/CHCl3 system

Highly efficient synthesis of capsaicin analogues was developed using condensation of vanillylamine with acyl chlorides in a biphase H2O/CHCl3 system under mild conditions. For C4-C18 aliphatic or aromatic acyl chlorides, the yields were up to 93-96% with high purity after a simple work-up procedure, and only 1-1.16 equiv of acyl chloride was needed in the reaction.