1050392-36-3

Basic information

• Product Name: 4-(5-amino-4-methylisothiazol-3-yl)phenol
• Synonyms: 4-(5-amino-4-methylisothiazol-3-yl)phenol
• CAS NO: 1050392-36-3
• Molecular Weight: 206.268
• Mol File: 1050392-36-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(5-amino-4-methylisothiazol-3-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-amino-4-methylisothiazol-3-yl)phenol(1050392-36-3)
• EPA Substance Registry System: 4-(5-amino-4-methylisothiazol-3-yl)phenol(1050392-36-3)

Safety Data

• Hazardous Substances Data: 1050392-36-3(Hazardous Substances Data)

Upstream product

• 1050392-29-4 3-(4-methoxy-phenyl)-4-methylisothiazol-5-ylamine 
• 874-90-8 4-methoxybenzonitrile 
• 767-00-0 4-cyanophenol 
• 1370439-26-1 C₁₀H₁₀N₂O 

Downstream Products

• 1050392-40-9 (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 
• 1050393-23-1 (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2-methylcyclopropanecarboxamide 

Relevant articles and documents

3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity

The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2- methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy.