1050445-45-8

Basic information

• Product Name: 2-(4-bromophenyl)-1,1,1-trifluorobutan-2-ol
• Synonyms: 2-(4-bromophenyl)-1,1,1-trifluorobutan-2-ol
• CAS NO: 1050445-45-8
• Molecular Weight: 283.088
• Mol File: 1050445-45-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-1,1,1-trifluorobutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-1,1,1-trifluorobutan-2-ol(1050445-45-8)
• EPA Substance Registry System: 2-(4-bromophenyl)-1,1,1-trifluorobutan-2-ol(1050445-45-8)

Safety Data

• Hazardous Substances Data: 1050445-45-8(Hazardous Substances Data)

Upstream product

• 381-88-4 1,1,1-trifluoro-2-butanone 
• 106-37-6 1.4-dibromobenzene 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 557-20-0 diethylzinc 

Relevant articles and documents

Catalytic enantioselective addition of diethylzinc to trifluoromethyl ketones

(Figure Presented) A procedure for nucleophilic addition of diethylzinc to trifluoramethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asymmetric variant producing tertiary alcohols with up to 61% ee when TBOX is used as catalyst is described.