105107-84-4

Basic information

• Product Name: cis-4-Phenylthio-L-proline hydrochloride
• Synonyms: Cis-4-Phenylthio-L-proline hydrochloride;(4S)-4-(Phenylthio)-L-proline hydrochloride;Cis-4-phenylthio-L-proline;L-Proline,4-(phenylthio)-, hydrochloride (1:1), (4S);cis-4-Phenylthio-L-Proline HCl;(2S,4S)-4-(phenylthio)pyrrolidine-2-carboxylic acid hydrochloride;cis-4-Phenylthio-L-proline hydrochloride(Zofenopril calcium)
• CAS NO: 105107-84-4
• Molecular Formula: BrH*C₁₁H₁₃NO₂S
• Molecular Weight: 259.75
• Mol File: 105107-84-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: cis-4-Phenylthio-L-proline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-Phenylthio-L-proline hydrochloride(105107-84-4)
• EPA Substance Registry System: cis-4-Phenylthio-L-proline hydrochloride(105107-84-4)

Safety Data

• Hazardous Substances Data: 105107-84-4(Hazardous Substances Data)

Usage

Description

cis-4-Phenylthio-L-proline hydrochloride, also known as (4S)-4-(Phenylthio)-L-proline, is an organic compound that serves as an impurity in the pharmaceutical drug Zofenopril (Z587000). It is characterized by its white solid appearance and possesses unique chemical properties that make it relevant in the context of pharmaceutical manufacturing and quality control.

Uses

Used in Pharmaceutical Manufacturing:
cis-4-Phenylthio-L-proline hydrochloride is used as a reference impurity for the drug Zofenopril (Z587000). Its presence is crucial for ensuring the purity and quality of the final drug product, as it helps in monitoring and controlling the manufacturing process to meet regulatory standards.
Used in Quality Control and Analysis:
In the pharmaceutical industry, cis-4-Phenylthio-L-proline hydrochloride is utilized as a benchmark for quality control and analytical testing. It aids in the development of methods to detect and quantify impurities, thereby ensuring the safety, efficacy, and consistency of the drug Zofenopril.
Used in Research and Development:
cis-4-Phenylthio-L-proline hydrochloride serves as a valuable compound in the research and development of new pharmaceuticals and drug formulations. Its unique chemical properties and role as an impurity in Zofenopril make it a useful tool for studying drug synthesis, stability, and potential interactions with other compounds.

InChI:InChI=1/C11H13NO2S.ClH/c13-11(14)10-6-9(7-12-10)15-8-4-2-1-3-5-8;/h1-5,9-10,12H,6-7H2,(H,13,14);1H/t9-,10-;/m0./s1

Upstream product

• 75176-28-2 N-(benzyloxycarbonyl)-cis-4-(phenylthio)-L-proline 
• 108-98-5 thiophenol 
• 57653-38-0 N-<(phenylmethoxy)carbonyl>-4(R)-<<(4-methylphenyl)sulfonyl>oxy>-(S)-proline methyl ester 
• 83623-88-5 (2S,4S)-4-(phenylsulfanyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 

Downstream Products

• 83552-04-9 (2S,4S)-4-Phenylsulfanyl-pyrrolidine-2-carboxylic acid methyl ester; hydrochloride 
• 83552-06-1 [1(S),4S]-1-[N-(1-Carboxy-3-phenylpropyl)-L-alanyl]-4-(phenylthio)-L-prolin 
• 83552-05-0 (2S,4S)-1-[(S)-2-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-4-phenylsulfanyl-pyrrolidine-2-carboxylic acid methyl ester 
• 81872-10-8 zofenopril 

Relevant articles and documents

PYRROLIDINE ANALOGUE FOR PREVENTING NEUROGENIC PAIN AND METHOD FOR PRODUCTION THEREOF

[Problems] To provide a pyrrolidine analogue having an inhibitory activity on the induction of allodynia, a method for producing the pyrrolidine analogue, and an agent for preventing a neurogenic pain. [Means for Solving the Problems] A pyrrolidine analog