10512-86-4

Basic information

• Product Name: N-FORMYL-L-ALANINE
• Synonyms: FOR-ALA-OH;FORMYL-L-ALANINE;formylalanine;L-Alanine,N-formyl-;N-ALPHA-FORMYL-L-ALANINE;N-FORMYL-L-ALANINE;L-Alanine, N-formyl- (7CI,9CI);(S)-2-(Formylamino)propionic acid
• CAS NO: 10512-86-4
• Molecular Formula: C₄H₇NO₃
• Molecular Weight: 117.1
• EINECS: 234-045-4
• Product Categories: GLYCINESCAFFOLD
• Mol File: 10512-86-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 147-148 °C
• Boiling Point: 386.6 °C at 760 mmHg
• Flash Point: 187.6 °C
• Appearance: /
• Density: 1.223 g/cm³
• Refractive Index: -32 ° (C=4, EtOH)
• Storage Temp.: Store at 0-5°C
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: N-FORMYL-L-ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-FORMYL-L-ALANINE(10512-86-4)
• EPA Substance Registry System: N-FORMYL-L-ALANINE(10512-86-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 10512-86-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C4H7NO3/c1-3(4(7)8)5-2-6/h2-3H,1H3,(H,5,6)(H,7,8)/t3-/m0/s1

Upstream product

• 64-18-6 formic acid 
• 56-41-7 L-alanin 
• 13549-49-0 2-(formamido)acrylic acid 
• 302-72-7 rac-Ala-OH 
• 2258-42-6 formyl acetic anhydride 
• 113388-44-6 (formyloxy)(acetoxy)phenylmethane 

Downstream Products

• 61167-49-5 N-formyl-L-alanine 4-nitrophenyl ester 
• 27646-78-2 (S)-(+)-2-(N-methylamino)propanol 
• 32221-83-3 (S)-N-formylalanine methyl ester 
• 69604-83-7 N-Formyl-L-alanine benzyl ester 
• 125698-55-7 C₁₄H₁₈N₂O₄ 

Relevant articles and documents

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Water-soluble chiral polyisocyanides showing thermoresponsive behavior

To afford chiral polyisocyanides with thermoresponsiveness may open new gates to enhance their functionality and to broaden their applications. Herein, we report the synthesis of a series of novel polyisocyanides carrying oligoethylene glycols (OEGs) modified dipeptides as the pendent groups. These polyisocyanides not only show different chiroptical properties but also possess characteristic thermoresponsive behavior. The corresponding monomers carrying different OEG units in the periphery are water-soluble, thus allowing their polymerization feasible in aqueous medium with NiCl2 as the catalyst. For comparison, polyisocyanides were also prepared in organic solvents, such as dichloromethane and tetrahydrofuran. The effects of solvent and polymerization temperature as well as chemical structures of the pendants on the chiroptical properties of the resulting polymers were examined. The characteristic thermoresponsive behavior of these chiral polymers was investigated by 1H NMR spectroscopy and turbidity measurements using UV/vis spectroscopy. The thermally induced aggregation processes were also followed by dynamic light scattering. It was found that the phase transition temperatures of these polymers were significantly influenced not only by the overall hydrophilicity but also by their secondary structures.

Enantioselective Rh-catalyzed hydrogenation of N-formyl dehydroamino esters with monodentate phosphoramidite ligands

Enantioselectivities up to >99% ee were achieved in the rhodium-catalyzed asymmetric hydrogenation of N-formyl dehydroamino esters using monodentate phosphoramidites as chiral ligands. The substrates were synthesized by condensation of methyl isocyanoacetate with a range of aldehydes and with cyclohexanone. A highly convenient multigram scale one step synthesis of methyl 2-(formamido)acrylate was developed. This compound was used in the synthesis of methyl 2-(formamido)cinnamate via a solvent free Heck reaction. Moreover, full conversion and >99% ee were obtained in 1 h in the hydrogenation of methyl 2-(formamido)acrylate with 0.2 mol% catalyst and 2 bar hydrogen pressure. The versatility of the formyl protection was established by its removal under mild conditions.

Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings

Residual dipolar couplings (RDC) emerged to be an important structural parameter for organic and biomolecules. Herein, a new helical polyisocyanopeptide (l,l-PIAF-OBn) that forms lyotropic liquid crystals (LLC) in CDCl3 is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application for the structural elucidation of strychnine and triptolide.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.