105130-26-5

Basic information

• Product Name: 4-(2-PYRIMIDINYLOXY)ANILINE
• Synonyms: 4-(2-pyrimidinyloxy)phenylamine;4-(2-PYRIMIDINYLOXY)ANILINE;4-(pyrimidin-2-yloxy)benzenamine
• CAS NO: 105130-26-5
• Molecular Formula: C₁₀H₉N₃O
• Molecular Weight: 187.2
• Mol File: 105130-26-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 140-142°
• Boiling Point: 394.1 °C at 760 mmHg
• Flash Point: 192.1 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 2.03E-06mmHg at 25°C
• Refractive Index: 1.632
• PKA: 3.93±0.10(Predicted)
• CAS DataBase Reference: 4-(2-PYRIMIDINYLOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PYRIMIDINYLOXY)ANILINE(105130-26-5)
• EPA Substance Registry System: 4-(2-PYRIMIDINYLOXY)ANILINE(105130-26-5)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 105130-26-5(Hazardous Substances Data)

Usage

General Description

4-(2-Pyrimidinyloxy)aniline is a chemical compound with the molecular formula C10H9N3O. It is an aromatic amine and aniline derivative, featuring a pyrimidine ring and an aniline group. 4-(2-Pyrimidinyloxy)aniline is used as a building block in organic synthesis and can be found in various chemical reactions and pharmaceutical compounds. It has potential application in the field of medicinal chemistry due to its unique structure and chemical properties. Additionally, its aromatic nature and reactivity make it a versatile compound for use in the development of new materials and chemical processes.

InChI:InChI=1/C10H9N3O/c11-8-2-4-9(5-3-8)14-10-12-6-1-7-13-10/h1-7H,11H2

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 123-30-8 4-amino-phenol 
• 100-02-7 4-nitro-phenol 
• 181801-29-6 4-(pyrimidin-2-yloxy)aniline 

Downstream Products

• 112283-18-8 2-nitro-N-((4-(pyrimidin-2-yloxy)phenyl)carbamoyl)benzamide 
• 1034358-28-5 (2R,3R)-3-{2-[4-(pyrimidin-2-yloxy)phenylamino]-5-trifluoromethylpyrimidin-4-ylamino}butan-2-ol 
• 1227486-42-1 tert-butyl (3S,4R)-4-({5-carbamoyl-2-[(4-hydroxyphenyl)amino]pyridin-4-yl}amino)-3-fluoropiperidine-1-carboxylate 
• 1227485-21-3 tert-butyl (3S,4R)-4-[(5-carbamoyl-2-{[4-(pyrimidin-2-yloxy)phenyl]amino}pyridin-4-yl)amino]-3-fluoropiperidine-1-carboxylate 

Relevant articles and documents

hTERT MODULATORS AND METHODS OF USE

The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

Benzoylphenylurea sulfur analogues with potent antitumor activity

A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was