1051316-46-1

Basic information

• Product Name: 6-(2-bromoethyl)quinoline
• Synonyms: 6-(2-bromoethyl)quinoline
• CAS NO: 1051316-46-1
• Molecular Weight: 236.111
• Mol File: 1051316-46-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(2-bromoethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-bromoethyl)quinoline(1051316-46-1)
• EPA Substance Registry System: 6-(2-bromoethyl)quinoline(1051316-46-1)

Safety Data

• Hazardous Substances Data: 1051316-46-1(Hazardous Substances Data)

Upstream product

• 5622-34-4 6-quinoline acetic acid 
• 227809-77-0 2-(quinolin-6-yl)ethan-1-ol 

Downstream Products

• 1051315-51-5 6-phenyl-2-(2-(quinolin-6-yl)ethyl)pyridazin-3(2H)-one 

Relevant articles and documents

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors

Discovery of the exceptionally powerful anticancer drug dolastatin 10 (1), contained in the sea hare Dolabella auricularia, opened a new frontier needed for improving human cancer treatment. Subsequently, major advances have been achieved based on results of structurally modifying this unusual natural peptide while maintaining the remarkable anticancer activity necessary for preparation of successful monoclonal antibody drug conjugates (ADC). Among the first several hundred SAR products based on dolastatin 10 our group synthesized and termed auristatins was auristatin E (2a). An anticancer activity-equivalent, desmethylaurisatin E (2b), linked to a CD30 monoclonal antibody is the very successful anticancer drug Adcetris, now approved for use in 65 countries. In the present investigation, we discovered a new subset of auristatins designated quinstatins derived from dolastatin 10 by replacing the C-terminal Doe unit with a carefully designed quinoline, which led to low or subnanomolar levels of cancer cell growth inhibition required for construction of chemically unique ADC drugs. The synthesis of quinstatins 2-8 is presented along with their cancer cell line biological data.

NITROGEN-CONTAINING HETEROCYCLYL KETONES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.