1051418-95-1 Usage
Description
d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one, also known as Nevirapine-d4, is an isotopically labeled research compound derived from Nevirapine. It is characterized by the presence of cyclopropyl-2,2,3,3-d4 and is used as an internal standard for the quantification of Nevirapine by GCor LC-MS. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to HIV-1 reverse transcriptase and inhibits RNA plus-strand initiation.
Uses
Used in Pharmaceutical Industry:
d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one is used as an internal standard for the quantification of Nevirapine by GCor LC-MS. This helps in the accurate measurement and analysis of Nevirapine in various pharmaceutical formulations.
Used in HIV Treatment:
d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one, as Nevirapine-d4, plays a crucial role in the development and evaluation of Nevirapine-based formulations for the treatment of HIV-1 infection. Nevirapine prevents seroconversion and viremia in a chimpanzee model of HIV-1 infection and is used in combination therapy for effective management of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 1051418-95-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,1,4,1 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1051418-95:
(9*1)+(8*0)+(7*5)+(6*1)+(5*4)+(4*1)+(3*8)+(2*9)+(1*5)=121
121 % 10 = 1
So 1051418-95-1 is a valid CAS Registry Number.
1051418-95-1Relevant articles and documents
PREPARATION AND UTILITY OF NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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, (2008/12/08)
Disclosed herein are non-nucleoside reverse transcriptase inhibitors having structural Formula ( I ), processes of preparation thereof, pharmaceutical compositions thereof, and the methods of their use thereof. Formula ( I )
