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105186-99-0

105186-99-0

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105186-99-0 Usage

Description

TGF-ALPHA, also known as Transforming Growth Factor-α, is a growth factor protein that belongs to the transforming growth factor-beta (TGF-β) superfamily. It plays a crucial role in cell proliferation, differentiation, and regulation of various cellular processes. TGF-ALPHA is involved in the signaling pathways that control cell growth and development, making it an essential component in the field of cell biology and medicine.
Source:
TGF-ALPHA is naturally produced by various human cells, including hepatocytes and keratinocytes.
Production Methods:
TGF-ALPHA is typically produced through the expression of the TNFα gene, which is mapped to human chromosome 6p21.33. The protein is synthesized and secreted by cells, where it can act in an autocrine or paracrine manner to regulate cellular processes.

Uses

Used in Cell Culture Applications:
TGF-ALPHA is used as a growth factor in cell culture applications for various cell types, such as sheep preantral follicles, human hepatocytes, and keratinocyte cell cultures. It helps determine the ideal concentration of growth factors required to support the growth and maintenance of these cells in vitro.
Used in Morphogenesis Applications:
In the field of developmental biology, TGF-ALPHA is used as an inducer of morphogenesis in primary mouse organoids. It plays a significant role in the formation and development of various tissues and organs during the organogenesis process.
Used in Pharmaceutical Industry:
TGF-ALPHA has potential applications in the pharmaceutical industry, particularly in the development of therapeutic strategies targeting cell growth and differentiation-related diseases. Its involvement in cellular signaling pathways makes it a promising candidate for the treatment of various conditions, including cancer and tissue repair.
Used in Research and Development:
TGF-ALPHA is also used in research and development settings to study the molecular mechanisms underlying cell growth, differentiation, and development. It serves as a valuable tool for understanding the complex signaling networks that regulate these processes and for identifying potential targets for therapeutic intervention.

Biochem/physiol Actions

The TNFA gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy.

Check Digit Verification of cas no

The CAS Registry Mumber 105186-99-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,1,8 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105186-99:
(8*1)+(7*0)+(6*5)+(5*1)+(4*8)+(3*6)+(2*9)+(1*9)=120
120 % 10 = 0
So 105186-99-0 is a valid CAS Registry Number.

105186-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Transforming Growth Factor-α human

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:105186-99-0 SDS

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