1051969-85-7Relevant articles and documents
Synthesis of a bridging ligand with a non-denatured protein pendant: Toward protein encapsulation in a coordination cage
Fujita, Daishi,Suzuki, Kosuke,Sato, Sota,Yagi-Utsumi, Maho,Kurimoto, Eiji,Yamaguchi, Yoshiki,Kato, Koichi,Fujita, Makoto
, p. 313 - 315 (2012)
Toward protein encapsulation by a synthetic host, we synthesized an ubiquitin-dangled ligand, a potential precursor of a nanoscale coordination cage. The key step is the addition of a C-terminal Cys76 SH group, which was introduced by Gly76Cys mutation, to a maleimide acceptor on the ligand. The C-terminal mutation and the SH addition to the ligand did not damage the ubiquitin moiety at all, neither structurally nor conformationally.
