105250-97-3

Basic information

• Product Name: 4(1H)-Quinazolinethione, 2-(4-chlorophenyl)-
• CAS NO: 105250-97-3
• Molecular Formula: C14H9ClN2S
• Molecular Weight: 272.758
• Mol File: 105250-97-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinethione, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinethione, 2-(4-chlorophenyl)-(105250-97-3)
• EPA Substance Registry System: 4(1H)-Quinazolinethione, 2-(4-chlorophenyl)-(105250-97-3)

Safety Data

• Hazardous Substances Data: 105250-97-3(Hazardous Substances Data)

Upstream product

• 37619-18-4 methyl 2-(4-chlorobenzamido)benzoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 104-88-1 4-chlorobenzaldehyde 
• 7455-77-8 2-(4-chlorophenyl)-4(3H)-quinazolinone 
• 13165-11-2 2-(4-Chloro-phenyl)-2,3-dihydro-1H-quinazolin-4-one 
• 28144-70-9 anthranilic acid amide 
• 2454-39-9 2-aminobenzothioamide 
• 100698-06-4 2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione pyridinium salt 
• 59525-09-6 4-chloro-N-(2-thiocarbamoyl-phenyl)-benzamide 

Downstream Products

• 105251-19-2 2-(4-chlorophenyl)-4-(propargylthio)quinazoline 
• 900613-41-4 C₁₅H₁₀ClN₅ 
• 315715-71-0 C₁₄H₁₁ClN₄ 
• 1429045-91-9 C₂₈H₁₉ClN₆S 
• 105251-02-3 3-(bromomethyl)-5-(4-chlorophenyl)-2,3-dihydrothiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-23-8 3-(bromomethyl)-5-(4-chlorophenyl)thiazolo<3,2-c>quinazolin-4-ium bromide 
• 105251-06-7 2-(4-chlorophenyl)-4-<(2,3-dibromopropyl)thio>quinazoline 
• 105250-99-5 4-(allylthio)-2-(4-chlorophenyl)quinazoline 

Relevant articles and documents

2-Alkyl(aryl)-quinazolin-4(3 H)-thiones, 2-R-(quinazolin-4(3 H)-ylthio)carboxylic acids and amides: Synthesis, molecular docking, antimicrobial and anticancer properties

In this study, a series of novel 2-alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides were synthesized and evaluated for antimicrobial and anticancer activities. Their structure was confirmed by elemental analys

Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines

In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright