1053163-67-9

Basic information

• Product Name: 3-cyclopropyl-1-methyl-1H-pyrazole
• Synonyms: 3-cyclopropyl-1-methyl-1H-pyrazole
• CAS NO: 1053163-67-9
• Molecular Formula: C7H10N2
• Molecular Weight: 122.1677
• Mol File: 1053163-67-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 212.9±9.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 2.66±0.10(Predicted)
• CAS DataBase Reference: 3-cyclopropyl-1-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopropyl-1-methyl-1H-pyrazole(1053163-67-9)
• EPA Substance Registry System: 3-cyclopropyl-1-methyl-1H-pyrazole(1053163-67-9)

Safety Data

• Hazardous Substances Data: 1053163-67-9(Hazardous Substances Data)

Usage

General Description

3-Cyclopropyl-1-methyl-1H-pyrazole, also known as CPMP, is a chemical compound with the molecular formula C6H8N2. It is a pyrazole derivative with a cyclopropyl group and a methyl group attached to the pyrazole ring. CPMP is used in the pharmaceutical industry as a building block for the synthesis of various bioactive compounds, including potential drugs with anti-inflammatory, analgesic, and anticonvulsant properties. In addition, it is also used as a ligand in coordination chemistry for the preparation of metal complexes. CPMP is classified as a hazardous chemical and should be handled and stored with caution due to its potential health and environmental risks.

Upstream product

• 21666-68-2 (E)-1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one 
• 60-34-4 methylhydrazine 
• 765-43-5 Cyclopropyl methyl ketone 
• 21666-68-2 1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one 
• 100114-57-6 3-cyclopropyl-1H-pyrazole 
• 77-78-1 dimethyl sulfate 
• 485-80-3 S-adenosyl-L-methionine 

Downstream Products

• 1257637-82-3 3-cyclopropyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 902837-67-6 3-cyclopropyl-1-methyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Engineered Enzymes Enable Selective N-Alkylation of Pyrazoles With Simple Haloalkanes

Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst-controlled pyrazole alkylation by a cyclic two-enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non-natural analogs of the common cosubstrate S-adenosyl-l-methionine. A second engineered enzyme transfers the alkyl group in highly selective C?N bond formations to the pyrazole substrate. The cosubstrate is recycled and only used in catalytic amounts. Key is a computational enzyme-library design tool that converted a promiscuous methyltransferase into a small enzyme family of pyrazole-alkylating enzymes in one round of mutagenesis and screening. With this enzymatic system, pyrazole alkylation (methylation, ethylation, propylation) was achieved with unprecedented regioselectivity (>99 %), regiodivergence, and in a first example on preparative scale.

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.