10532-63-5

Basic information

• Product Name: Cyanamide, (2-methylphenyl)-
• CAS NO: 10532-63-5
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Mol File: 10532-63-5.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Cyanamide, (2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyanamide, (2-methylphenyl)-(10532-63-5)
• EPA Substance Registry System: Cyanamide, (2-methylphenyl)-(10532-63-5)

Safety Data

• Hazardous Substances Data: 10532-63-5(Hazardous Substances Data)

Upstream product

• 87169-07-1 Thiocyanato-essigsaeure-o-toluidid 
• 614-68-6 2-tolyl isocyanate 
• 40312-14-9 N'-hydroxy-2-methylbenzamidine 
• 95-53-4 o-toluidine 
• 614-69-7 2-tolyl isothiocyanate 
• 506-68-3 bromocyane 
• 14683-79-5 salicylaldoxime 
• 529-20-4 2-methylphenyl aldehyde 
• 10468-64-1 o-tolyl isocyanide 
• 94-69-9 2'-methylformanilide 
• 615-37-2 ortho-methylphenyl iodide 
• 420-04-2 CYANAMID 
• 372-09-8 cyanoacetic acid 
• 611-21-2 N,2-dimethylaniline 

Downstream Products

• 6268-14-0 N-phenyl-N'-o-tolyl-guanidine 
• 614-77-7 N-(2-methylphenyl)urea 
• 95-53-4 o-toluidine 
• 128413-99-0 N-((3S,8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N'-o-tolyl-guanidine 
• 128414-02-8 N-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-N'-o-tolyl-guanidine 
• 128413-39-8 N-(2,6-Dimethyl-phenyl)-N'-o-tolyl-guanidine 
• 128413-44-5 N-(3-Hydroxy-phenyl)-N'-o-tolyl-guanidine 
• 128413-91-2 N-(1R,2R,4S)-Bicyclo[2.2.1]hept-2-yl-N'-o-tolyl-guanidine 
• 128763-50-8 4-Methyl-5-o-tolylamino-2,4-dihydro-[1,2,4]triazole-3-thione 
• 128413-36-5 N-(2-Iodo-phenyl)-N'-o-tolyl-guanidine 
• 128413-53-6 N-[2-((E)-Styryl)-phenyl]-N'-o-tolyl-guanidine 
• 127866-79-9 1-(2-methylphenyl)-5-amino-1H-tetrazole 
• 261943-62-8 N-(2-methylphenyl)-1H-tetrazol-5-amine 
• 108719-43-3 2-(N-(2-tolyl)amino)quinazoline-4-one 

Relevant articles and documents

Sodium bis(trimethylsilyl)amide in the 'one-flask' transformation of isocyanates to cyanamides

Cyanamides were successfully prepared in a 'one-flask' reaction from isocyanates by use of sodium bis(trimethylsilyl)amide as the deoxygenating agents in THF at room temperature. Georg Thieme Verlag Stuttgart.

One-Pot Synthesis of N-Monosubstituted Ureas from Nitriles via Tiemann Rearrangement

Amidoximes, obtained from the reaction of nitriles with hydroxylamine, underwent Tiemann rearrangement in the presence of benzenesulfonyl chlorides (TsCl or o-NsCl) to form the N-substituted cyanamides. Subsequently, acidic hydrolysis of the cyanamides afforded the corresponding N-monosubstituted ureas. The synthesis of N-monosubstituted ureas from nitriles was accomplished by three steps in one pot, which provides a direct access to versatile N-monosubstituted urea derivatives from a wide variety of nitriles.

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.