105336-57-0

Basic information

• Product Name: 2-(3,4-dimethylphenyl)-2-phenylacetonitrile
• Synonyms: 2-(3,4-dimethylphenyl)-2-phenylacetonitrile
• CAS NO: 105336-57-0
• Molecular Weight: 221.302
• Mol File: 105336-57-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethylphenyl)-2-phenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethylphenyl)-2-phenylacetonitrile(105336-57-0)
• EPA Substance Registry System: 2-(3,4-dimethylphenyl)-2-phenylacetonitrile(105336-57-0)

Safety Data

• Hazardous Substances Data: 105336-57-0(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 14189-53-8 3,4-dimethylbenzhydrol 
• 583-71-1 4-bromo-o-xylene 
• 140-29-4 phenylacetonitrile 
• 95-47-6 o-xylene 
• 119718-87-5 cyano(phenyl)methyl acetate 

Relevant articles and documents

Zn(OTf)2 - Catalyzed direct cyanation of benzylic alcohols - A novel synthesis of α-aryl nitriles

This work demonstrates an efficient method to prepare α-aryl nitriles by direct cyanation of benzylic alcohol with TMSCN in the presence of a catalytic amount of Zn(OTf)2 under heating condition. A variety of benzylic alcohols can be converted into the corresponding α-aryl nitriles in good to excellent yields. 2012 Elsevier Ltd. All rights reserved.

Reaction of 4-Bromo-1,2-dimethylbenzene with Various Nucleophiles via Aryne Reaction

4-Bromo-1,2-dimethylbenzene (4a) reacts with a variety of amines, mercaptans, and nitriles under aryne-forming conditions to yield predominantly 4-substituted 1,2-dimethylbenzenes and minor quantities of 3-substituted 1,2-dimethylbenzenes.The product distributions from these reactions are heavily in favor of the 4-substituted isomer since it is formed exclusively from the symmetric 4,5-dimethylbenzyne intermediate (6) and partly from the unsymmetric 3,4-dimethylbenzyne intermediate (5).