105360-03-0

Basic information

• Product Name: 11-(2-Dimethylamino-ethylsulfanyl)-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid ethyl ester
• CAS NO: 105360-03-0
• Molecular Weight: 385.527
• Mol File: 105360-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11-(2-Dimethylamino-ethylsulfanyl)-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(2-Dimethylamino-ethylsulfanyl)-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid ethyl ester(105360-03-0)
• EPA Substance Registry System: 11-(2-Dimethylamino-ethylsulfanyl)-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid ethyl ester(105360-03-0)

Safety Data

• Hazardous Substances Data: 105360-03-0(Hazardous Substances Data)

Upstream product

• 138639-85-7 2-Bromo-4-methyl-11-(tetrahydro-pyran-2-yloxy)-6,11-dihydro-dibenzo[b,e]oxepine 
• 106044-88-6 11-Hydroxy-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid ethyl ester 
• 13242-44-9 2-(N,N-dimethylamino)ethylthiol hydrochloride 

Downstream Products

• 105360-09-6 11-(2-Dimethylamino-ethylsulfanyl)-4-methyl-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid; hydrochloride 

Relevant articles and documents

A new series of antiallergic agents. II. Synthesis and activity of new 6,11-dihydrodibenz[b,e]oxepin-carboxylic acid derivatives

New methods for the preparation of multi-functionalized-6,11-dihydrodibenz[b,e]oxepins were developed. The structural requirements of KW-4994 (1), a promising orally active antiallergic agent, were defined. A carboxyl group at C-2 was critical for enhanced antiallergic activity of 1. The introduction of bromine atom at C-9 of 1 could elongate the duration of the action of the parent. Antiplatelet activity, a new pharmacological property of this series of compounds, was observed in one of the derivatives of 1.