1053636-56-8Relevant articles and documents
Synthesis and antiviral activity of the α-analogues of 1,5-anhydrohexitol nucleosides (1,5-anhydro-2,3-dideoxy-D-ribohexitol nucleosides)
Hossain,Rozenski,De Clercq,Herdewijn
, p. 2442 - 2447 (1997)
1,5-Anhydro-2,3-dideoxy-D-ribohexitol nucleosides were synthesized starting from 4,6-di-O-benzyl-1,5-di-O-pivaloyl-3-deoxy-D-glucitol using a ring closure procedure. The target nucleoside adopts a 4C1 conformation as also demonstrated for the corresponding 1,5-anhydrohexitol nucleosides with β-configuration of the base-substituted carbon atom. The cytosine congener demonstrated a moderate but selective activity against Herpes simplex virus types 1 and 2.