1053735-50-4

Basic information

• Product Name: 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester
• CAS NO: 1053735-50-4
• Molecular Weight: 588.623
• Mol File: 1053735-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester(1053735-50-4)
• EPA Substance Registry System: 5-(4-{4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-4-methoxycarbonyl-butylcarbamoyl)-pyridine-2-carboxylic acid methyl ester(1053735-50-4)

Safety Data

• Hazardous Substances Data: 1053735-50-4(Hazardous Substances Data)

Upstream product

• 149010-73-1 methyl N^δ-(tert-butoxycarbonyl)-N^α-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-ornithinate 
• 149010-53-7 4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid 
• 51186-41-5 methyl N^δ-(tert-butoxycarbonyl)-L-ornithinate 
• 17874-76-9 6-(methoxycarbonyl)nicotinic acid 

Relevant articles and documents

Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutam ic acid (1b, TNP-351) and the related compound (1a), was replaced with various N(ω)-acyl-, sulfonyl-, carbamoyl- and aryl-2,ω-diaminoalkanoic acids,