10540-41-7

Basic information

• Product Name: 4'-FLUORO[1,1'-BIPHENYL]-3-OL
• Synonyms: AKOS BAR-1060;4'-FLUORO[1,1'-BIPHENYL]-3-OL
• CAS NO: 10540-41-7
• Molecular Formula: C₁₂H₉FO
• Molecular Weight: 188.2
• Mol File: 10540-41-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-FLUORO[1,1'-BIPHENYL]-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO[1,1'-BIPHENYL]-3-OL(10540-41-7)
• EPA Substance Registry System: 4'-FLUORO[1,1'-BIPHENYL]-3-OL(10540-41-7)

Safety Data

• Hazardous Substances Data: 10540-41-7(Hazardous Substances Data)

Usage

General Description

4'-Fluoro[1,1'-biphenyl]-3-ol, also known as 4'-fluoro-3-biphenylol, is an organic compound with the molecular formula C12H9FO. It is a derivative of biphenyl with a fluorine atom attached to the fourth carbon of one of the phenyl rings and a hydroxyl group attached to the third carbon of the other phenyl ring. This chemical is commonly used in organic synthesis and pharmaceutical research as a building block for more complex molecules. It may also have potential applications in the field of material science due to its unique structure and properties.

Upstream product

• 462-06-6 fluorobenzene 
• 626-02-8 3-Iodophenol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 108-95-2 phenol 
• 111945-91-6 4'-fluoro-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 
• 10540-43-9 4'-fluoro-3-methoxy-1,1'-biphenyl 
• 10365-98-7 3-methoxyphenylboronic acid 
• 78494-26-5 3-(4-fluorophenyl)cyclohexan-1-one 
• 1765-93-1 4-fluoroboronic acid 
• 591-20-8 3-Bromophenol 
• 69-72-7 salicylic acid 
• 90-02-8 salicylaldehyde 
• 437-29-6 tris(4-fluorophenyl)bismuthane 

Downstream Products

• 141106-46-9 8-(4-fluorophenyl)-3,4-dihydro-2H-1-benzoxepin-5-one 
• 170639-08-4 [8-(4-Fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-pentyl-amine 
• 170639-07-3 [8-(4-Fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-hexyl-amine 
• 170639-09-5 [8-(4-Fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-nonyl-amine 
• 170639-10-8 [8-(4-Fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepin-5-yl]-(4-propoxy-butyl)-amine 
• 141106-48-1 (+/-)-N-8-(4-fluorophenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-yl-N₁-n-heptylamine 

Relevant articles and documents

Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenols

Aromatic molecules are key constituents of many pharmaceuticals, electronic materials, and commodity plastics. The utility of these molecules directly reflects the identity and pattern of substituents on the aromatic ring. Here, we report a palladium(II) catalyst system, incorporating an unconventional ortho-dimethylaminopyridine ligand, for the conversion of substituted cyclohexanones to the corresponding phenols. The reaction proceeds via successive dehydrogenation of two saturated carbon-carbon bonds of the six-membered ring and uses molecular oxygen as the hydrogen acceptor. This reactivity demonstrates a versatile and efficient strategy for the synthesis of substituted aromatic molecules with fundamentally different selectivity constraints from the numerous known synthetic methods that rely on substitution of a preexisting aromatic ring.

Photocatalyzed Transition-Metal-Free Oxidative Cross-Coupling Reactions of Tetraorganoborates**

Readily accessible tetraorganoborate salts undergo selective coupling reactions under blue light irradiation in the presence of catalytic amounts of transition-metal-free acridinium photocatalysts to furnish unsymmetrical biaryls, heterobiaryls and arylated olefins. This represents an interesting conceptual approach to forge C?C bonds between aryl, heteroaryl and alkenyl groups under smooth photochemical conditions. Computational studies were conducted to investigate the mechanism of the transformation.

Lewis acid-promoted site-selective cyanation of phenols

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.