10541-29-4Relevant articles and documents
N-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates
Magre, Marc,Szewczyk, Marcin,Rueping, Magnus
, p. 3209 - 3214 (2020)
A new reduction of carbamates to N-methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.
N -Monomethylation of amines using paraformaldehyde and H2
Wang, Hongli,Huang, Yongji,Dai, Xingchao,Shi, Feng
supporting information, p. 5542 - 5545 (2017/07/06)
The selective N-monomethylation of amines is an important topic in fine chemical synthesis. Herein, for the first time, we described a selective N-monomethylation reaction of amines with paraformaldehyde and H2 in the presence of a CuAlOx catalyst. A variety of amines, including primary aromatic amines, benzylamine and cyclohexylamine, as well as secondary amines, have been shown to be compatible with this reaction.