1054605-79-6Relevant articles and documents
Highly stereoselective syntheses of syn- and anti-1,2-amino alcohols
Hoffman, Robert V.,Maslouh, Najib,Cervantes-Lee, Francisco
, p. 1045 - 1056 (2007/10/03)
The reduction of N-protected amino ketones can be carried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer. Carbamate-protected amino ketones can be reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78°C. N-Trityl-protected amino ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5°C.