105462-25-7

Basic information

• Product Name: 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)
• CAS NO: 105462-25-7
• Molecular Weight: 283.114
• Mol File: 105462-25-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: >236°C (dec.)
• Boiling Point: 694.7±65.0 °C(Predicted)
• Density: 1.870±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)(105462-25-7)
• EPA Substance Registry System: 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid)(105462-25-7)

Safety Data

• Hazardous Substances Data: 105462-25-7(Hazardous Substances Data)

Usage

Description

1-Hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) is a chemical compound characterized by its unique structure, which features a central carbon atom bonded to two phosphonic acid groups and a hydroxyl group. It also has a pyridin-4-yl group attached to the central carbon atom, which contributes to its specific properties and potential applications.

Uses

Used in Pharmaceutical Industry:
1-Hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) is used as a key component in the preparation of bisphosphonates for the pharmaceutical industry. Its ability to inhibit Trypanosoma cruzi hexokinase makes it a promising candidate for the development of new drugs targeting this enzyme, which is involved in the pathogenesis of Chagas disease.
Used in Biological Studies:
In the field of biological research, 1-hydroxy-2-(pyridin-4-yl)ethane-1,1-diyl bis(phosphonic acid) serves as an important tool for studying the structure and function of various enzymes and biological pathways. Its specific interactions with target proteins can provide valuable insights into the mechanisms of enzyme inhibition and the development of novel therapeutic strategies.

Upstream product

• 28356-58-3 pyridine-4-acetic acid 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 

Relevant articles and documents

SKELETAL REMOVAL OF BISPHOSPHONATES

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.

Novel procedure for the synthesis of 1-hydroxy-1,1-bisphosphonic acids using phenols as medium

A facile synthetic route for the synthesis of bisphosphonates in phenols is described. Preparations of some of bisphosphonates, which are presently in clinical use such as risedronic acid and alendronate sodium, are synthesized following this new, simple method. This procedure can be useful for the synthesis of this class of bone-resorptive inhibitors in bulk quantities. Copyright Taylor & Francis Group, LLC.

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A potential route to chemotherapy

We have investigated the effects in vitro of a series of bisphosphonates on the proliferation of Trypanosoma cruzi, Trypanosoma brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum. The results show that nitrogen-containing bisphosphonates of the type used in bone resorption therapy have significant activity against parasites, with the aromatic species having in some cases nanomolar or low-micromolar IC50 activity values against parasite replication (e.g. o-risedronate, I50 = 220 nM for T. brucei rhodesiense; risedronate, IC50 = 490 nM for T. gondii). In T. cruzi, the nitrogen-containing bisphosphonate risedronate is shown to inhibit sterol biosynthesis at a pre-squalene level, most likely by inhibiting farnesylpyrophosphate synthase. Bisphosphonates therefore appear to have potential in treating parasitic protozoan diseases.